Nod Signaling Adaptor Proteins
Cytosolic signaling adaptor proteins that were initially discovered by their role in the innate immunity (IMMUNITY, INNATE) response of organisms that lack an adaptive immune system. This class of proteins contains three domains, a C-terminal ligand recognition domain, an N-terminal effector-binding domain, and a centrally located nuclear-binding oligomerization domain. Many members of this class contain a C-terminal leucine rich domain which binds to PEPTIDOGLYCAN on the surface of BACTERIA and plays a role in pathogen resistance.
Year introduced: 2007
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Subheadings:
Tree Number(s): D12.644.360.024.313, D12.644.360.539.500, D12.776.157.057.078, D12.776.476.024.391
MeSH Unique ID: D053472
Entry Terms:
- Nuclear-Binding Oligomerization Domain Proteins
- Nuclear Binding Oligomerization Domain Proteins
- Nucleotide Oligomerization Domain Proteins
- NOD Leucine-Rich Repeat Proteins
- NOD Leucine Rich Repeat Proteins
- NOD-LRR Signaling Adaptor Proteins
- NOD LRR Signaling Adaptor Proteins