Analysis of wildtype BY4742 yeast cultures treated with clioquinol (CQ), a hydrophobic chelator of copper, zinc, and iron in vitro. CQ significantly decreased amyloid-beta levels in a mouse model of Alzheimer's disease (AD). Results provide insight into molecular mechanisms underlying CQ action.
Li C, Wang J, Zhou B. The metal chelating and chaperoning effects of clioquinol: insights from yeast studies. J Alzheimers Dis 2010;21(4):1249-62. PMID: 21504115