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Status |
Public on May 21, 2010 |
Title |
Expression data of Saccharomyces cerevisiae treated with clioquinol |
Platform organisms |
Schizosaccharomyces pombe; Saccharomyces cerevisiae |
Sample organism |
Saccharomyces cerevisiae |
Experiment type |
Expression profiling by array
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Summary |
Clioquinol (CQ or iodochlorhydroxyquin, 5-chloro-7-iodo-8-hydroxyquinoline) is a hydrophobic chelator of copper, zinc, and iron. It was extensively used as an antibiotic for the treatment of diarrhea and skin infection in the mid-1900s, but then withdrawn because it was reported to be associated with subacute myelo-optic neuropathy (SMON) in Japan. Interest in this drug was recently revived as it was shown that CQ specifically kills cancer cells and significantly decreases Aβ level. Nevertheless, the underlying mechanisms of CQ’s drug effects and side effects are still unclear.
We used yeast, Saccharomyces cerevisiae, as a model to study how CQ affects molecular and cellular functions. Genechip analysis was utilized to examine the effect of CQ on gene expression at the genomic level.
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Overall design |
To study gene expression profiles of yeast treated with CQ, yeast cells were treated with CQ or DMSO for 5 hours and RNAs were extracted for microarray analysis.
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Contributor(s) |
Li C, Zhou B |
Citation(s) |
21504115 |
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Submission date |
Jul 22, 2009 |
Last update date |
Feb 21, 2017 |
Contact name |
Chenghua Li |
E-mail(s) |
ch-li06@mails.thu.edu.cn
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Organization name |
Tsinghua University
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Department |
Biological Sciences and Technology
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Street address |
Qinghuayuan
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City |
Beijing |
ZIP/Postal code |
100084 |
Country |
China |
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Platforms (1) |
GPL2529 |
[Yeast_2] Affymetrix Yeast Genome 2.0 Array |
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Samples (6)
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GSM432203 |
yeast treated with DMSO, biological rep1 |
GSM432204 |
yeast treated with DMSO, biological rep2 |
GSM432205 |
yeast treated with DMSO, biological rep3 |
GSM432206 |
yeast treated with CQ, biological rep1 |
GSM432207 |
yeast treated with CQ, biological rep2 |
GSM432208 |
yeast treated with CQ, biological rep3 |
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Relations |
BioProject |
PRJNA118941 |
Supplementary file |
Size |
Download |
File type/resource |
GSE17257_RAW.tar |
5.8 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
Processed data included within Sample table |
Processed data provided as supplementary file |
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