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Series GSE17257 Query DataSets for GSE17257
Status Public on May 21, 2010
Title Expression data of Saccharomyces cerevisiae treated with clioquinol
Platform organisms Schizosaccharomyces pombe; Saccharomyces cerevisiae
Sample organism Saccharomyces cerevisiae
Experiment type Expression profiling by array
Summary Clioquinol (CQ or iodochlorhydroxyquin, 5-chloro-7-iodo-8-hydroxyquinoline) is a hydrophobic chelator of copper, zinc, and iron. It was extensively used as an antibiotic for the treatment of diarrhea and skin infection in the mid-1900s, but then withdrawn because it was reported to be associated with subacute myelo-optic neuropathy (SMON) in Japan. Interest in this drug was recently revived as it was shown that CQ specifically kills cancer cells and significantly decreases Aβ level. Nevertheless, the underlying mechanisms of CQ’s drug effects and side effects are still unclear.

We used yeast, Saccharomyces cerevisiae, as a model to study how CQ affects molecular and cellular functions. Genechip analysis was utilized to examine the effect of CQ on gene expression at the genomic level.
 
Overall design To study gene expression profiles of yeast treated with CQ, yeast cells were treated with CQ or DMSO for 5 hours and RNAs were extracted for microarray analysis.
 
Contributor(s) Li C, Zhou B
Citation(s) 21504115
Submission date Jul 22, 2009
Last update date Feb 21, 2017
Contact name Chenghua Li
E-mail(s) ch-li06@mails.thu.edu.cn
Organization name Tsinghua University
Department Biological Sciences and Technology
Street address Qinghuayuan
City Beijing
ZIP/Postal code 100084
Country China
 
Platforms (1)
GPL2529 [Yeast_2] Affymetrix Yeast Genome 2.0 Array
Samples (6)
GSM432203 yeast treated with DMSO, biological rep1
GSM432204 yeast treated with DMSO, biological rep2
GSM432205 yeast treated with DMSO, biological rep3
Relations
BioProject PRJNA118941

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE17257_RAW.tar 5.8 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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