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    MAP1LC3C microtubule associated protein 1 light chain 3 gamma [ Homo sapiens (human) ]

    Gene ID: 440738, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MAP1LC3Cprovided by HGNC
    Official Full Name
    microtubule associated protein 1 light chain 3 gammaprovided by HGNC
    Primary source
    HGNC:HGNC:13353
    See related
    Ensembl:ENSG00000197769 MIM:609605; AllianceGenome:HGNC:13353
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LC3C; ATG8J
    Summary
    Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
    Expression
    Biased expression in placenta (RPKM 3.9), lung (RPKM 1.9) and 9 other tissues See more
    Orthologs
    all
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    Genomic context

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    See MAP1LC3C in Genome Data Viewer
    Location:
    1q43
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (241995490..242001393, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (241407557..241413464, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (242158792..242162400, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene beclin 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:242153743-242154242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:242162385-242162910 Neighboring gene cofilin 1 pseudogene 4 Neighboring gene NANOG hESC enhancer GRCh37_chr1:242172315-242172816 Neighboring gene RNA, U6 small nuclear 1139, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:242220644-242221384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:242223521-242224022 Neighboring gene tubulin beta 8 class VIII pseudogene 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion. Bell ES, et al. Cell Rep, 2019 Dec 17. PMID 31851933
    2. LC3C mediates selective autophagy of the MET RTK, inhibiting cancer cell invasion. Bell ES, et al. Autophagy, 2020 May. PMID 32065021, Free PMC Article
    3. Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells. Verma R, et al. J Biol Chem, 2023 May. PMID 37003503, Free PMC Article
    4. Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells. Cho HS, et al. Tissue Eng Regen Med, 2021 Apr. PMID 33230801, Free PMC Article
    5. Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site. Krichel C, et al. Sci Rep, 2019 Oct 2. PMID 31578424, Free PMC Article

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis.
      Title: Reticulophagy mediated by the V-ATPase-ATG16L1-LC3C axis.
    2. Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells.
      Title: Microtubule-associated protein MAP1LC3C regulates lysosomal exocytosis and induces zinc reprogramming in renal cancer cells.
    3. ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway.
      Title: ATG5 selectively engages virus-tethered BST2/tetherin in an LC3C-associated pathway.
    4. PGM5P3-AS1 regulates MAP1LC3C to promote cell ferroptosis and thus inhibiting the malignant progression of triple-negative breast cancer.
      Title: PGM5P3-AS1 regulates MAP1LC3C to promote cell ferroptosis and thus inhibiting the malignant progression of triple-negative breast cancer.
    5. TFG binds LC3C to regulate ULK1 localization and autophagosome formation.
      Title: TFG binds LC3C to regulate ULK1 localization and autophagosome formation.
    6. Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.
      Title: Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide.
    7. Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells.
      Title: Autophagy-Related Protein MAP1LC3C Plays a Crucial Role in Odontogenic Differentiation of Human Dental Pulp Cells.
    8. LC3C mediates selective autophagy of the MET RTK, inhibiting cancer cell invasion.
      Title: LC3C mediates selective autophagy of the MET RTK, inhibiting cancer cell invasion.
    9. Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C.
      Title: Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C.
    10. Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site.
      Title: Solution structure of the autophagy-related protein LC3C reveals a polyproline II motif on a mobile tether with phosphorylation site.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 Nef-treated mesenchymal stem cells downregulates the conversion of LC3I to LC3II, reflecting a decrease in autophagic efflux in cells PubMed
    Vif vif HIV-1 Vif binds more strongly to autophagy-related protein 4 (ATG4)-cleaved form I (LC3-I) than to ATG4-cleaved form II (LC3-II) in an A3G-independent manner PubMed
    vif The domain 144-159 inside the SOCS box-like motif of HIV-1 Vif and the glycine 120 of microtubule-associated protein light chain 3 (LC3) are required for the binding between Vif and LC3 PubMed
    vif GST pull-down assay demonstrates that HIV-1 Vif physically interacts with light chain 3 proteins LC3A, LC3B, and LC3C in HEK cells PubMed
    capsid gag HIV-1 CA co-localizes with LC3 in Jurkat cells and primary CD4+ T cells PubMed
    retropepsin gag-pol HIV-1 protease extensively cleaves microtubule-associated proteins 1 and 2 and completely inhibits microtubule assembly PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylethanolamine binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in aggrephagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome maturation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macroautophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein exit from endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in autophagosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in autophagosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in organelle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    microtubule-associated proteins 1A/1B light chain 3C
    Names
    LC3-like protein 2
    MAP1 light chain 3-like protein 2
    MAP1 light chain 3-like protein 3
    MAP1A/MAP1B LC3 C
    MAP1A/MAP1B light chain 3 C
    autophagy-related protein LC3 C
    autophagy-related ubiquitin-like modifier LC3 C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004343.3 → NP_001004343.1  microtubule-associated proteins 1A/1B light chain 3C

      See identical proteins and their annotated locations for NP_001004343.1

      Status: VALIDATED

      Source sequence(s)
      AF276659, BC127722, BX571673, CN260933
      Consensus CDS
      CCDS31074.1
      UniProtKB/Swiss-Prot
      A0PJY8, A2RUP0, Q9BXW4
      Related
      ENSP00000349785.3, ENST00000357246.4
      Conserved Domains (1) summary
      cd01611
      Location:13 → 126
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      241995490..242001393 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005273139.4 → XP_005273196.1  microtubule-associated proteins 1A/1B light chain 3C isoform X1

      See identical proteins and their annotated locations for XP_005273196.1

      UniProtKB/Swiss-Prot
      A0PJY8, A2RUP0, Q9BXW4
      Conserved Domains (1) summary
      cd01611
      Location:13 → 126
      GABARAP; Ubiquitin domain of GABA-receptor-associated protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      241407557..241413464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054336691.1 → XP_054192666.1  microtubule-associated proteins 1A/1B light chain 3C isoform X1

      UniProtKB/Swiss-Prot
      A0PJY8, A2RUP0, Q9BXW4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BXW4.1 GenPept UniProtKB/Swiss-Prot:Q9BXW4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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