sting1 stimulator of interferon response cGAMP interactor 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sting1provided by ZNC
Official Full Name: stimulator of interferon response cGAMP interactor 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-120921-1
See related: Ensembl:ENSDARG00000091058 AllianceGenome:ZFIN:ZDB-GENE-120921-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tmem173
Summary: Predicted to enable 2',3'-cyclic GMP-AMP binding activity and cyclic-di-GMP binding activity. Involved in positive regulation of macroautophagy. Acts upstream of or within several processes, including NIK/NF-kappaB signaling; defense response to other organism; and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (7764375..7786400, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (7457966..7479862, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suppressors of cGAS-STING are downregulated during fin-limb regeneration and aging in aquatic vertebrates.
Title: Suppressors of cGAS-STING are downregulated during fin-limb regeneration and aging in aquatic vertebrates.
A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING.
Title: A zebrafish NLRX1 isoform downregulates fish IFN responses by targeting the adaptor STING.
CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection.
Title: CRISPR/Cas9-Induced Knockout of Sting Increases Susceptibility of Zebrafish to Bacterial Infection.
Taken together, these findings suggest that grass carp reovirus VP41 prevents the fish interferon response by attenuating the phosphorylation of MITA for viral evasion.
Title: Grass Carp Reovirus VP41 Targets Fish MITA To Abrogate the Interferon Response.
Silencing of zSTING, but not zMAVS, markedly attenuates the simplex virus 1-induced antiviral responses.
Title: Conservation of the STING-Mediated Cytosolic DNA Sensing Pathway in Zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 2',3'-cyclic GMP-AMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclic-di-GMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables proton channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in autophagosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cGAS/STING signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cytoplasmic pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of defense response to virus by host	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macroautophagy	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of non-canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of type I interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of autophagy	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reticulophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in autophagosome	IBA Inferred from Biological aspect of Ancestor more info
located_in autophagosome membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum-Golgi intermediate compartment membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: stimulator of interferon genes protein

Names: ERIS; MITA; MPYS; STING; transmembrane protein 173

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001278837.1 → NP_001265766.1 stimulator of interferon genes protein

See identical proteins and their annotated locations for NP_001265766.1

Status: PROVISIONAL

Source sequence(s)

HE856619

UniProtKB/TrEMBL

K4Q6R6

Conserved Domains (1) summary

pfam15009
Location:42 → 328

TMEM173; Transmembrane protein 173

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

7764375..7786400 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005157121.4 → XP_005157178.1 stimulator of interferon genes protein isoform X1

UniProtKB/Swiss-Prot

E7F4N7, K4Q6R6

Related

ENSDARP00000105858.1, ENSDART00000128218.3

Conserved Domains (1) summary

pfam15009
Location:42 → 328

TMEM173; Transmembrane protein 173