GEO DataSets

(Submitter supplied) We propose the hypothesis that loss of estrogen receptor function which leads to endocrine resistance in breast cancer, also results in de-differentiation from an epithelial to a mesenchymal phenotype that is responsible for increased aggressiveness and metastatic propensity. siRNA mediated silencing of the estrogen receptor in MCF7 breast cancer cells resulted in estrogen/tamoxifen resistant cells (pII) with altered morphology, increased motility with rearrangement and switch from an actin to a vimentin based cytoskeleton, and ability to invade simulated components of the extracellular matrix. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4061

Platform:

GPL570

6 Samples

Download data: CEL

Analysis of MCF7 breast cancer cells after siRNA-mediated silencing of the estrogen receptor α (ERα). The induced ERα silencing resulted in estrogen/tamoxifen resistant cells (pII). Results provide insight into molecular events underlying the endocrine drug resistant phenotype in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:

GPL570

Series:

GSE27473

6 Samples

Download data: CEL