GEO DataSets for BioProject (Select 189236) - GEO DataSets

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Items: 2

Select item 2000442441.

PAX5 overexpression is not enough to reestablish the mature B-cell phenotype in classical Hodgkin lymphoma

(Submitter supplied) In lymphomas derived from mature B cells the expression of the transcription factor PAX5 is maintained whereas classical Hodgkin lymphoma displays significantly reduced PAX5 expression despite its derivation from mature B cells. To elucidate the functional role of PAX5 in classical Hodgkin lymphoma, we re-established the PAX5 expression in the Hodgkin cell line L428 with and without epigenetic modulation. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4978
Platform:: GPL6244
18 Samples

Download data: CEL

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Accession:: GSE44244

ID:: 200044244

Select item 49782.

Transcription factor Pax5 overexpression in Hodgkin lymphoma cell line L428

Analysis of classical Hodgkin lymphoma (cHL) cell line L428 stably-transfected with a mifepristone-inducible PAX5-expression system. The L428-PAX5 cells were epigenetically modified by 5-aza-2'-deoxycytidine/TSA treatment. Results provide insight into the role of PAX5 in cHL.