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Items: 3

1.
Full record GDS5820

αSMA+ myofibroblast early depletion effect on pancreatic ductal adenocarcinoma model

Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 4 to 4.5 weeks of age for 14 days or less to selectively deplete αSMA+ myofibroblasts. Results provide insight into the role of αSMA+ myofibroblasts in early-stage PDAC.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6887
Series:
GSE52812
6 Samples
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2.
Full record GDS5821

αSMA+ myofibroblast late depletion effect on pancreatic ductal adenocarcinoma model

Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 6 weeks of age for 10 days or less to selectively deplete αSMA+ myofibroblasts. Results provide insight into the role of αSMA+ myofibroblasts in late-stage PDAC.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6887
Series:
GSE52812
6 Samples
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3.
Full record GDS5822

Anti-CTLA-4 immunotherapy effect on αSMA+ myofibroblast late-depleted pancreatic ductal adenocarcinoma model

Analysis of pancreatic ductal adenocarcinoma (PDAC) tumors from PKT; αSMA-tk+ transgenics injected daily with ganciclovir at 6 weeks of age for 10 days or less to deplete αSMA+ myofibroblasts and treated with anti-CTLA4. Results provide insight into molecular basis of anti-CTLA4 therapy in PDAC.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 2 protocol sets
Platform:
GPL6887
Series:
GSE52812
9 Samples
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