GPL10123[Accession] - GEO DataSets - NCBI

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Select item 2002489811.

DBF4, not DRF1, is the crucial regulator of CDC7 kinase at replication forks.

(Submitter supplied) In eukaryotes, CDC7 kinase is crucial for DNA replication initiation and has been involved in fork processing and replication stress response. Human CDC7 requires the binding of either one of two regulatory subunits, DBF4 and DRF1, for its activity. However, it is unclear whether the two regulatory subunits target CDC7 to a specific set of substrates, thus having different biological functions, or if they act redundantly. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL10123
12 Samples

Download data: BED, TXT

Series

Accession:: GSE248981

ID:: 200248981

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002549362.

Proteogenomic analysis reveals adaptive strategies to alleviate the consequences of aneuploidy in cancer

(Submitter supplied) Aneuploidy is prevalent in cancer, conferring fitness advantage, multidrug resistance, and poor prognosis. In contrast, experimentally induced aneuploidy often results in adverse effects and impaired proliferation. This paradox underscores the necessity of cancer cells to adapt to abnormal chromosome numbers. To identify molecular mechanisms of adaptation to aneuploidy, we initiated in vitro evolution of cells with extra chromosomes added via microcell-mediated chromosome transfer. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL5477 GPL10123
13 Samples

Download data: TXT

Series

Accession:: GSE254936

ID:: 200254936

Select item 2001532303.

Integrated copy number and transcriptomic profiling reveal novel oncogenic drivers and clinically significant biomarkers in adenoid cystic carcinoma

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome variation profiling by genome tiling array

Platforms:: GPL10123 GPL4091 GPL6244
137 Samples

Download data: CEL, CHP, TXT

Series

Accession:: GSE153230

ID:: 200153230

PubMed Similar studies Analyze with GEO2R

Select item 2001532284.

Integrated copy number and transcriptomic profiling reveal novel oncogenic drivers and clinically significant biomarkers in adenoid cystic carcinoma [Agilent]

(Submitter supplied) We analyzed 100 patient samples by high-resolution arrayCGH to study genomic imbalances in ACC.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL10123 GPL4091
100 Samples

Download data: TXT

Series

Accession:: GSE153228

ID:: 200153228

PubMed Similar studies

Select item 2001808655.

GNL3/nucleostemin links DNA replication homeostasis and replication forks stability

(Submitter supplied) The regulation of replication forks stalling and replication origins firing must be tightly coordinated to prevents genomic instability. Here we show that GNL3/nucleostemin, a GTP-binding protein able to shuttle between the nucleolus and the nucleoplasm, limits replicative stress by limiting replication origins firing. GNL3 is in proximity of nascent DNA and its depletion reduces forks speed but increases forks density and replication origins firing. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platform:: GPL10123
6 Samples

Download data: TXT

Series

Accession:: GSE180865

ID:: 200180865

Analyze with GEO2R

Select item 2001805306.

Palbociclib interferes with origin firing in a pRb independent manner

(Submitter supplied) Over the last decade, CDK4/6 inhibitors (palbociclib, ribociclib and abemaciclib) have emerged as promising anticancer drugs. Numerous studies have demonstrated that CDK4/6 inhibitors efficiently block the pRb-E2F pathway and induce cell cycle arrest in pRb-proficient cells. Based on these studies, the inhibitors have been approved by the FDA for treatment of advanced hormonal receptor (HR) positive breast cancers in combination with hormonal therapy. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
10 Samples

Download data: TXT

Series

Accession:: GSE180530

ID:: 200180530

Analyze with GEO2R

Select item 2001014477.

Intratumor heterogeneity in metastic endometrial carcinoma

(Submitter supplied) Endometrial cancer (EC) is the most common female genital malignancy and the fourth most common cancer in women in the developing world1. EC has been traditionally classified into two main groups with different clinical, pathological and molecular features2,3. Type I or endometrioid endometrial carcinomas (EECs) account for about 75% of the cases and are typically estrogen-related and low-grade tumors with good prognosis that coexist or are preceded by endometrial hyperplasia, mainly diagnosed in perimenopausal women. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
18 Samples

Download data: TXT

Series

Accession:: GSE101447

ID:: 200101447

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001560768.

The genomic landscape of colitis-associated colorectal carcinomas is dominated by TP53 mutations, aneuploidy and gains of chromosome arm 5p

(Submitter supplied) Ulcerative colitis associated colorectal tumors were characterized by array-based comparative genomic hybridization to elucidate chromosomal aneuploidy patterns.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
23 Samples

Download data: TXT

Series

Accession:: GSE156076

ID:: 200156076

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001789279.

DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability

(Submitter supplied) The DNA polymerase zeta (Polζ) plays a critical role in bypassing DNA damage. REV3L, the catalytic subunit of Polζ is also essential in mouse embryonic development and cell proliferation for reasons that remain incompletely understood. In this study, we reveal that REV3L protein interacts with heterochromatin components including repressive histone marks, and localizes in pericentromeric regions through direct interaction with HP1 dimer. more...

Organism:: Homo sapiens; Mus musculus

Type:: Other

Platforms:: GPL10123 GPL10449
6 Samples

Download data: TXT

Series

Accession:: GSE178927

ID:: 200178927

Analyze with GEO2R

Select item 20015661810.

Replication timing data for six human cell lines under aphidicolin treatment (t0) and after release (N+1)

(Submitter supplied) DNA replication is very well orchestrated in mammalian cells due to a tight regulation of the temporal order of replication origin activation, known as the replication timing program. The replication timing of a given replication domain is very robust and well conserved in each cell type. Upon low replication stress, the slowing of replication forks induces delayed replication of some fragile regions leading to DNA damage and genetic instability. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL10123
37 Samples

Download data: BED, TXT

Series

Accession:: GSE156618

ID:: 200156618

PubMed Full text in PMC Similar studies

Select item 20013866511.

Single-cell RNA-seq reveals intratumoral heterogeneity in primary uveal melanomas

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by genome tiling array; Other

Platforms:: GPL10123 GPL18573 GPL11154
18 Samples

Download data: H5, TXT, VCF

Series

Accession:: GSE138665

ID:: 200138665

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013840412.

Array CGH analysis of human uveal melanomas

(Submitter supplied) Primary uveal melanomas show multiple chromosomal aberrations. To identify genome variation in six human primary uveal melanomas, genome wide copy number variation (CNV) analyses were carried out in human primary uveal melanoma samples using array comparative genome hybridization.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
6 Samples

Download data: TXT

Series

Accession:: GSE138404

ID:: 200138404

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20011891013.

Analysis of copy number variation (CNV) in human induced hepatic progenitor cells (hiHepPCs) by aCGH

(Submitter supplied) CNV comparison of human umvilical vein endothelial cells (HUVECs) and hiHepPCs generated from HUVECs transduced with defined transcription factors.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
4 Samples

Download data: TXT

Series

Accession:: GSE118910

ID:: 200118910

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014534114.

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome variation profiling by array

4 related Platforms
208 Samples

Download data: TXT

Series

Accession:: GSE145341

ID:: 200145341

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014534015.

19p loss is significantly enriched in older age neuroblastoma patients and correlates with poor prognosis (Agilent-022060)

(Submitter supplied) Genomic aberrations of neuroblastoma occurring in late childhood and adolescence are uncommon and still underestimated. Public DNA copy number profiles of 556 tumors (discovery set) and of 208 tumors obtained by array-CGH assay (validation set) were used to verify if 19p loss is significantly over-represented in children and adolescents. The 19p loss occurrence was separately tested within different age groups in the discovery and validation set and the resulting P values were combined and corrected by Bonferroni’s method. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by array

Platform:: GPL10123
24 Samples

Download data: TXT

Series

Accession:: GSE145340

ID:: 200145340

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20014112216.

New, easy, quick and efficient DNA replication timing analysis by high-throughput approaches

(Submitter supplied) DNA replication must be faithful and follow a well-defined spatio-temporal program closely linked to genomic organization, transcription, epigenomic marks, intra-nuclear structures, mutation rate and cell fate determination. Replication timing (RT) analyses require complex, precise and time-consuming experimental procedures, and the study of large-size computer files. We improved the RT protocol to speed up and increase its quality and reproducibility. more...

Organism:: Homo sapiens

Type:: Other

Platforms:: GPL10152 GPL10123
7 Samples

Download data: TXT

Series

Accession:: GSE141122

ID:: 200141122

Analyze with GEO2R

Select item 20013120017.

Detection of tetraploidization in chromophobe renal cell carcinoma: insights and pitfalls [Agilent CGH]

(Submitter supplied) Detection of tetraploidization in chromophobe renal cell carcinoma.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
19 Samples

Download data: TXT

Series

Accession:: GSE131200

ID:: 200131200

Analyze with GEO2R

Select item 20011078518.

Whole genome copy number profiles of FFPE samples from patients with metasatic colorectal cancer (mCRC)

(Submitter supplied) Metastatic colorectal cancer (mCRC) is associated with multiple somatic copy number alterations (SCNAs). We analyzed SCNAs to estimate overall survival (OS) and progression free suvival (PFS) for mCRC patients treated with bevacizumab in combination with oxaliplatin or irinotecan.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
154 Samples

Download data: TXT

Series

Accession:: GSE110785

ID:: 200110785

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010366519.

Copy number alteration burden is a pan-cancer prognostic factor associated with metastasis and death in conservatively treated prostate cancer: TAPG1 CNA cohort aCGH data

(Submitter supplied) The level of copy number alteration (CNA), or CNA burden, in cancer genomes is associated with recurrence and metastasis in prostate cancer. As clinical genomic analysis of tumors and tumor biopsies becomes widespread, there is a growing need to understand the prognostic factors captured by genomic features, especially in prostate cancer where conservative treatment approaches are increasingly common. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platforms:: GPL10152 GPL10123
107 Samples

Download data: TXT

Series

Accession:: GSE103665

ID:: 200103665

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010677320.

ArrayCGH on a cohort of pediatric T-ALL cases characterized by TCRAD-MYC translocation

(Submitter supplied) ArrayCGH was performed on a cohort of 25 specimens collected from children with newly diagnosed T-ALL characterized by TCRAD-MYC translocation ArrayCGH analyses were perfomed to study genomic aberrations occurring in the rare subgroup of TCRAD-MYC rearranged T-ALL

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL10123
25 Samples

Download data: TXT, XLSX

Series

Accession:: GSE106773

ID:: 200106773

Analyze with GEO2R

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GPL10123[Accession] (1423)
GEO DataSets
Exophiala mesophila strain CCFEE 6314 scaffold_17, whole genome shotgun sequence
Exophiala mesophila strain CCFEE 6314 scaffold_17, whole genome shotgun sequence
gi|1552503414|gb|NAJM01000017.1||gn :NAJM01|scaffold_17

Nucleotide
Generic sample from Solanum tuberosum
Generic sample from Solanum tuberosum

biosample
Microbe sample from Lacticaseibacillus paracasei
Microbe sample from Lacticaseibacillus paracasei

biosample
Scleria tristis voucher A.V. Scatigna s/n (UEC) external transcribed spacer, par...
Scleria tristis voucher A.V. Scatigna s/n (UEC) external transcribed spacer, partial sequence
gi|2042698112|gb|MT966634.1|

Nucleotide

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