GPL10669[RGSE] - GEO DataSets

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Select item 2002763821.

Prenatal Maternal Stress in Rats Alters the Epigenetic and Transcriptomic Landscape of the Maternal-Fetal Interface Across Four Generations [methylation]

(Submitter supplied) Prenatal maternal stress (PNMS) determines lifetime mental and physical health. Here, we show in rats that PNMS has consequences for placental function and fetal brain development across four generations (F0-F3). Using a systems biology approach, comprehensive DNA methylation (DNAm), miRNA, and mRNA profiling revealed a moderate impact of PNMS in the F1 generation, but drastic changes in F2 and F3 generations, suggesting compounding effects of PNMS with each successive generation. more...

Organism:: Rattus norvegicus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL10669
42 Samples

Download data: BEDGRAPH

Series

Accession:: GSE276382

ID:: 200276382

Select item 2002762262.

Prenatal Maternal Stress in Rats Alters the Epigenetic and Transcriptomic Landscape of the Maternal-Fetal Interface Across Four Generations [miRNA]

Organism:: Rattus norvegicus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL10669
41 Samples

Download data: TXT

Series

Accession:: GSE276226

ID:: 200276226

Select item 2001793803.

LSD influences gene expression patterns within the mammalian brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL10669 GPL85
26 Samples

Download data: CEL

Series

Accession:: GSE179380

ID:: 200179380

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001793794.

Chronic LSD alters gene expression profiles in the mPFC relevant to schizophrenia [RNA-seq]

(Submitter supplied) Chronic administration of lysergic acid diethylamide (LSD) every other day to rats results in a variety of abnormal behaviors. These build over the 90 day course of treatment and can persist at full strength for at least several months after cessation of treatment. The behaviors are consistent with those observed in animal models of schizophrenia and include hyperactivity, reduced sucrose-preference, and decreased social interaction. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10669
20 Samples

Download data: TXT

Series

Accession:: GSE179379

ID:: 200179379

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001730855.

Identification of significantly differential expression of long noncoding RNAs and pathways in hepatic fibrosis rat liver issues

(Submitter supplied) Objective: To identify the long noncoding (lncRNA) and its potential roles in hepatic fibrosis rat liver issues induced by CCl4. Methods: LncRNAs and genes were analyzed in fibrosis rat liver issues by RNA sequencing and verified by quantitative reverse transcription polymerase chain reaction (qRT-PCR). Differential expressed lncRNAs and genes were subjected to bioinformatics analysis and involved to construct co-expression network.

Organism:: Rattus norvegicus

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL10669
6 Samples

Download data: TXT

Series

Accession:: GSE173085

ID:: 200173085

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001473356.

Gene expression profile of metabolic dysfunction in the aorta of male Sprague-Dawley rats following a short-term high fat diet

(Submitter supplied) Diet-induced metabolic dysfunction precedes multiple disease states, including diabetes, heart disease, and atherosclerosis. The critical role of the vasculature in disease progression is established, yet the details of how gene expression changes in early cardiovascular disease remain an enigma. The objective of the current project was to evaluate whether a quantitative assessment of gene expression within the aorta of six-week old healthy male Sprague-Dawley rats compared to those exhibiting metabolic dysfunction symptoms could reveal potential mediators of vascular dysfunction.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10669
4 Samples

Download data: DAT

Series

Accession:: GSE147335

ID:: 200147335

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001336967.

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

(Submitter supplied) We have previously reported that the cardenolide drug digitoxin blocks TNFα/NFκB-driven proinflammatory signaling. We therefore hypothesized that digitoxin might break the collaborative process between NFκB and TGFβ by also inhibiting expression of TGFBR2. We therefore tested whether TGFβ-driven EMT and resulting metastases would be suppressed.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10669
6 Samples

Download data: TXT

Series

Accession:: GSE133696

ID:: 200133696

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001260578.

Deletion of the KH1 domain coding sequence of Fmr1 leads to transcriptional alterations and attentional deficits in rats

(Submitter supplied) We found that the previously published Fmr1 knockout rat model of FXS expresses an Fmr1 transcript with an in-frame deletion of exon 8, which encodes for the K-homology (KH) RNA-binding domain, KH1. We observed that the deletion of exon 8 in 10 male rats within the medial prefrontal cortex (mPFC) led to transcriptional alterations compared to 12 WT rats using RNAseq. Additionally, we used weighted gene co-expression network analysis to generate 23 modules specific to the mPFC with tissue from 35 WT rat samples.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10669
45 Samples

Download data: XLSX

Series

Accession:: GSE126057

ID:: 200126057

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001220069.

Profiling of 18 - 45 nt small RNAs in the cauda epididymal sperm of mice and rats.

(Submitter supplied) Total RNAs were extracted from the purified cauda epididymal spermatozoa of mouse (C57BL/6, 2 months old) and rats (Sprague Dawley, 450g young adult), and the 18 - 45 nt fraction small RNAs were subjected to library construction and deep sequencing, using Illumina GAIIx.

Organism:: Mus musculus; Rattus norvegicus

Type:: Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL11002 GPL10669
2 Samples

Download data: TXT

Series

Accession:: GSE122006

ID:: 200122006

PubMed Similar studies SRA Run Selector

Select item 20006268810.

Transcriptome profiling based study of early gene responses in susceptible and tolerant rat lung tissues during acute hypobaric hypoxia

(Submitter supplied) Aim: Acute hypobaric hypoxia occurs during fast ascent and brief sojourns to high altitudes. We aimed to elucidate early phase molecular mechanisms during hypobaric hypoxia that may contribute towards differential physiological responses in susceptible and tolerant rats. Methods: Sprague-Dawley rats representing susceptible, normal (moderate) and tolerant male and female groups were subjected to simulated acute hypobaric hypoxia for one hour at 9144 m and 24°C. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL10669
5 Samples

Download data: XLS

Series

Accession:: GSE62688

ID:: 200062688

SRA Run Selector

Select item 20010783711.

Transcriptomics but not DNA methylomics find Tp73, Cebpd, Pax6 and Spi1 transcription factors as treatment targets for traumatic brain injury

(Submitter supplied) TBI was induced with lateral fluid-percussion injury in adult male rats. MBD-seq of the perilesional cortex, ipsilateral thalamus and ipsilateral hippocampus was performed at 3 months post-TBI. The data was used to identify differential methylation of gene promoter, gene body, and exons in the perilesional cortex , thalamus and hippocampus.

Organism:: Rattus norvegicus

Type:: Methylation profiling by high throughput sequencing

Platforms:: GPL14844 GPL10669
30 Samples

Download data: TXT

Series

Accession:: GSE107837

ID:: 200107837

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010301112.

Identification of genes expressed in a mesenchymal subset regulating prostate organogenesis using tissue and single cell transcriptomics

(Submitter supplied) Prostate organogenesis involves epithelial growth in response to inductive signalling from specialised subsets of mesenchyme. To identify regulators and morphogens active in mesenchyme, we performed transcriptomic analysis using Tag-seq, RNA-seq, and single cell RNA-seq and defined new mesenchymal subsets and markers. We documented transcript expression using Tag-seq and RNA-seq in female rat Ventral Mesenchymal Pad (VMP) as well as adjacent urethra comprised of smooth muscle and peri-urethral mesenchyme. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL10669 GPL14844
119 Samples

Download data: CSV

Series

Accession:: GSE103011

ID:: 200103011

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007972713.

microRNA profiling in normal and hyperplastic human and murine parathyroid glands

(Submitter supplied) Secondary hyperparathyroidism (SHP) is a common complication of chronic kidney disease (CKD) and correlates with morbidity and mortality. In this study we profiled microRNAs (miRNA) in parathyroids from different experimental SHP models and uremic patients and studied the function of specific miRNA using antagonizing oligonucleotides (anti-miRs). miRNA profiles established by small RNA deep sequencing showed that human, rat and mouse parathyroids share the same most abundant miRNAs. more...

Organism:: Mus musculus; Homo sapiens; Rattus norvegicus

Type:: Non-coding RNA profiling by high throughput sequencing

4 related Platforms
55 Samples

Download data: XLSX

Series

Accession:: GSE79727

ID:: 200079727

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009400814.

Genome-wide identification of glucocorticoid receptor binding sites in the whole hippocampus of adrenalectomised male rats given corticosterone infusion and stressed or non-stressed.

(Submitter supplied) We have applied next-generation sequencing technology to obtain high through-put profiling of glucocorticoid receptor (GR) DNA binding in whole hippocampus from male rat brain. By obtaining sequence from immunoprecipitated, sonicated chromatin, we have generated genome-wide binding maps for GR in two contexts, testing whether chromatin is primed for GR binding according to the animal's acute experience. more...

Organism:: Rattus norvegicus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL10669
8 Samples

Download data: BEDGRAPH, CSV

Series

Accession:: GSE94008

ID:: 200094008

PubMed Full text in PMC Similar studies

Select item 20008017415.

Analysis of Post-TBI Gene Expression Signature Reveals Tubulins, NFE2L2, NFkB, CD44, and S100A4 as Treatment Targets for Traumatic Brain Injury

(Submitter supplied) TBI was induced with lateral fluid-percussion injury in adult male rats. Genome-wide RNA-seq of the perilesional cortex, ipsilateral thalamus and dorsal hippocampus was performed at 3 months post-TBI. The data highlighted chronic transcriptional changes, particularly, in the perilesional cortex and thalamus. Genes showing a significantly altered expression both in the cortex and thalamus were submitted to the LINCS web query to identify novel pharmacotherapies to improve post-TBI outcome.