GEO DataSets

(Submitter supplied) Hibernation is energy saving adaptation involving suppression of activity to survive in highly seasonal environments. Immobility and disuse generate muscle loss in most mammalian species. In contrast to other mammals, bears and ground squirrels demonstrate limited muscle atrophy over the physical inactivity of winter hibernation. This suggests that hibernating mammals have adaptive mechanisms to prevent disuse muscle atrophy. more...

Organism:

Ursus americanus

Type:

Expression profiling by array

Platform:

GPL13263

12 Samples

Download data: TXT

(Submitter supplied) Physical inactivity reduces mechanical load on the skeleton, which leads to losses of bone mass and strength in non hibernating mammalian species. Although bears are largely inactive during hibernation, they show no loss in bone mass and strength. To obtain insight into molecular mechanisms preventing disuse bone loss, we conducted a large-scale screen of transcriptional changes in trabecular bone comparing winter hibernating and summer non hibernating black bears using a custom 12,800 probe cDNA microarray. more...

Organism:

Ursus americanus

Type:

Expression profiling by array

Platforms:

GPL8249 GPL13263

24 Samples

Download data: TXT

(Submitter supplied) We analyzed gene expression in the American black bear, Ursus americanus, using a custom 12,800 cDNA probe (BA02) microarray to detect differences in expression that occur in heart and liver during winter hibernation in comparison to summer active animals. We identified 245 genes in heart and 319 genes in liver that were differentially expressed between winter and summer. The expression of 24 genes was significantly elevated during hibernation in both heart and liver. more...

Organism:

Ursus americanus

Type:

Expression profiling by array

Platforms:

GPL8249 GPL13263

35 Samples

Download data: TXT