GPL18020[Accession] - GEO DataSets

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Select item 2001655781.

Microenvironment Impacts the Molecular Architecture and Interactivity of Resident Cells in Marmoset Brain

(Submitter supplied) We sought to define and compare the diversity of cells across many brain areas, including various white matter (WM) regions, the volume and complexity of which is limited in mouse brain. We employed magnetic resonance (MR) image-guided sampling and snRNA-seq to survey the transcriptome at cellular resolution. Tissue types included WM (frontal, parietal, temporal), corpus callosum (anterior, posterior), optic tract, cerebral cortex (frontal, parietal, temporal, occipital, cingulate), caudate, hippocampus, lateral geniculate nucleus, cerebellum, thalamus, midbrain, pons, and cervical spinal cord. more...

Organism:: Callithrix jacchus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL18020 GPL28240 GPL26566
42 Samples

Download data: CSV, RDATA

Series

Accession:: GSE165578

ID:: 200165578

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001616452.

scAAVengr, a transcriptome-based pipeline for quantitative ranking of engineered AAVs with single-cell resolution

(Submitter supplied) Adeno-associated virus (AAV)-mediated gene therapies are rapidly advancing to the clinic, and AAV engineering has resulted in vectors with increased ability to deliver therapeutic genes. Although the choice of vector is critical, quantitative comparison of AAVs, especially in large animals, remains challenging. Here, we developed an efficient single-cell AAV engineering pipeline (scAAVengr) to simultaneously quantify and rank efficiency of competing AAV vectors across all cell types in the same animal. more...

Organism:: Macaca fascicularis; Callithrix jacchus; Mus musculus

Type:: Expression profiling by high throughput sequencing

5 related Platforms
147 Samples

Download data: CSV, MTX, TSV, TXT

Series

Accession:: GSE161645

ID:: 200161645

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000550233.

Transcriptional responses of Middle East respiratory syndrome coronavirus (MERS-CoV) in marmosets

(Submitter supplied) The absence of a robust disease model currently hinders the evaluation of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV that results in mild-to-moderate disease has been utilized to describe the pathogenesis of this virus and for the evaluation of therapeutics, the inability to produce uniform disease with substantial virus replication complicates analysis in countermeasure studies. more...

Organism:: Callithrix jacchus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18020
43 Samples

Download data: TXT

Series

Accession:: GSE55023

ID:: 200055023

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000529274.

Small RNA and gene expression profile in the adult testes of the common marmoset

(Submitter supplied) Small RNAs mediate gene silencing by binding Argonaute/Piwi proteins to regulate target RNAs. Here we describe small RNA profiling of the adult testes of Callithrix jacchus, the common marmoset. The most abundant class of small RNAs in the adult testis was piRNAs, while 353 novel miRNAs but few endo-siRNAs were also identified. MARWI, a marmoset homolog of mouse MIWI and a very abundant PIWI in adult testes, associates with piRNAs that show characteristics of mouse pachytene piRNAs. more...