GEO DataSets

(Submitter supplied) Diverse chemical modifications fine-tune the function and metabolism of tRNA. Although tRNA modification is universal in all kingdoms of life, profiles of modifications, their functions, and physiological roles have not been elucidated in most organisms including the human pathogen, Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis. To identify physiologically important modifications, we surveyed the tRNA of Mtb, using tRNA sequencing (tRNA-seq). more...

Organism:

Escherichia coli; Mycobacterium tuberculosis

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL16085 GPL19272

12 Samples

Download data: CSV

(Submitter supplied) The purpose of this study was to examine the impact of 2-aminoimidazoles on M. tuberculosis transcriptional responese.

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17879 GPL19272

7 Samples

Download data: XLSX

(Submitter supplied) Most eukaryotic mRNAs are enzymatically processed before they are translated, but less is known about mRNA processing in prokaryotes. While bacterial rRNAs and tRNAs are known to be highly processed, only a handful of bacterial mRNAs have been shown to be processed by ribonucleases, typically altering transcript stability. We hypothesized that mRNA processing might be more widespread in prokaryotes and constitute a previously underappreciated layer of post-transcriptional regulation. more...

Organism:

Mycobacterium tuberculosis

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL15138 GPL19272

9 Samples

Download data: TXT