U.S. flag

An official website of the United States government

Format
Items per page
Sort by

Send to:

Choose Destination

Search results

Items: 1 to 20 of 1487

1.

Kinase activity of nuclear TYRO3 promotes colon cancer malignancy

(Submitter supplied) The goal of this study is to compare the different biological functions between nuclear (ICD)-TYRO3- and kinase dead (KD)-TYRO3-overexpressed cells by BRD3 occupancy profiling. We revel that ICD-TYRO3-overexpressed cell were particularly enriched in negatively regulate cell death, regulation of cell cycle, regulation of vascular permeability, positively regulation of EMT, cell-cell adhesion, and regulation of phosphorylation.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21697
2 Samples
Download data: TXT
Series
Accession:
GSE188378
ID:
200188378
2.

Integrative analysis of patient-derived tumoroids and ex vivo organoid modeling of ARID1A loss in bladder cancer reveals therapeutic molecular targets

(Submitter supplied) Somatic mutations in ARID1A (AT-rich interactive domain-containing protein 1A) are present in approximately 25% of bladder cancers (BC) and are associated with poor prognosis. With a view to discover effective treatment options for ARID1A-deficient BC patients, we set out to identify targetable effectors dysregulated consequent to ARID1A deficiency. Integrative analyses of ARID1A depletion in normal organoids and data mining in publicly available datasets revealed upregulation of DNA repair and cell cycle-associated genes consequent to loss of ARID1A and identified CHEK1 (Checkpoint kinase 1) and chromosomal passenger complex member BIRC5 (Baculoviral IAP Repeat Containing 5) as therapeutically drug-able candidate molecular effectors. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL17303 GPL21697
40 Samples
Download data: TXT
Series
Accession:
GSE271565
ID:
200271565
3.

SUV39H1 Maintains Cancer Stem Cells in Glioblastoma [ATAC-seq]

(Submitter supplied) Glioblastoma (GBM) is the deadliest brain cancer, driven in part by GBM stem cells (GSCs) that contribute to therapeutic resistance and tumor recurrence. Effective targeting and elimination of GSCs hold promise for preventing GBM recurrence and achieving potential cures. In this study, we explored the role of the epigenetic regulator SUV39H1 in GSC maintenance and GBM progression. We observed that SUV39H1 is upregulated in GBM samples compared to normal brain tissues. more...
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21697
4 Samples
Download data: BED, BW
Series
Accession:
GSE273013
ID:
200273013
4.

Maintenance and functional regulation of immune memory to COVID-19 vaccines in tissues

(Submitter supplied) Memory T and B cells in lymphoid and mucosal tissues maintain long-term protection, though their generation following vaccination remains challenging to assess in humans. Here, we investigated immune memory generated to COVID-19 mRNA vaccines across blood, lymphoid organs, and lungs from 42 vaccinated organ donors aged 23-86, of whom 57% were previously infected with SARS-CoV-2. Using high-dimensional profiling, we reveal that Spike (S)-reactive memory T cells distribute in lymphoid organs and lungs, variably express tissue resident markers based on infection history, and exhibit site-specific compositions of effector and regulatory memory T cells. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL24676 GPL21697
82 Samples
Download data: TXT
Series
Accession:
GSE261278
ID:
200261278
5.

Classification of pediatric soft and bone sarcomas using DNA methylation-based profiling

(Submitter supplied) Pediatric sarcomas present heterogeneous morphology, genetics and clinical behavior posing a challenge for an accurate diagnosis. DNA methylation is an epigenetic modification that coordinates chromatin structure and regulates gene expression, determining cell type and function. DNA methylation-based tumor profiling classifier for sarcomas (known as sarcoma classifier) from the German Cancer Research Center (Deutsches Krebsforschungszentrum) was applied to 122 pediatric sarcomas referred to a reference pediatric oncology hospital. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL34281 GPL21697
14 Samples
Download data: CSV
Series
Accession:
GSE275159
ID:
200275159
6.

Transcriptomic changes in HCT116 cells after KAT2A knockout

(Submitter supplied) We were interested in transcriptional changes after depletion of histone acetyltransferase KAT2A in human colorectal cancer. Therefore, we utilized HCT116 cells as model, and analyzed global alterations of gene expression.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
6 Samples
Download data: XLSX
Series
Accession:
GSE246881
ID:
200246881
7.

single-cell RNA-seq analysis of 2 ovary tissues as part of creating a ovary cell atlas

(Submitter supplied) We aimed to create an ovary cell atlas using publicly available RNA-seq data. To complement the data we sequenced 2 ovary tissue samples from patients undergoing elective surgery at the JR hospital in Oxford. We applied single-nucei sequencing using the 10x Chromium technology.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
2 Samples
Download data: H5
Series
Accession:
GSE278300
ID:
200278300
8.

m6Am sequesters PCF11 to promote full-length transcription [m6ACE]

(Submitter supplied) RNA modifications regulate how RNAs metabolize and function to impact development and diseases. N6,2’-O-dimethyladenosine (m6Am) is one such modification and despite being abundant, m6Am function remains unclear. Here, we identified cleavage and polyadenylation factor, PCF11 as a m6Am-specific binding protein. Direct quantification of mature versus nascent RNAs revealed that m6Am does not regulate mRNA stability but promotes transcription of nascent RNAs. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL24676 GPL20795 GPL21697
36 Samples
Download data: BEDGRAPH, XLSX
Series
Accession:
GSE254149
ID:
200254149
9.

m6Am sequesters PCF11 to promote full-length transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
6 related Platforms
99 Samples
Download data: BED, BEDGRAPH, BW
Series
Accession:
GSE234137
ID:
200234137
10.

Synonymous mitochondrial DNA variation impairs CD8 T cell fate via codon affinity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Other
Platforms:
GPL24676 GPL21697
21 Samples
Download data: CSV, H5, MTX, TSV, TXT
Series
Accession:
GSE216915
ID:
200216915
11.

Synonymous mitochondrial DNA variation impairs CD8 T cell fate via codon affinity [mitoRiboseq]

(Submitter supplied) Somatic variation contributes to biological heterogeneity by modulating the cellular proclivity to differentiate, expand, adapt, or die. While large-scale sequencing efforts have revealed the foundational role of somatic variants to drive human tumor evolution, our understanding of the contribution of somatic variation to modulate cellular fitness in non-malignant contexts remains understudied. Here, we identify a somatic synonymous variant (m.7076A>G) in the mitochondrial DNA (mtDNA) encoded cytochrome c-oxidase subunit 1 gene (COX1), which was present at homoplasmy in 47% of immune cells from a healthy donor. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL21697
12 Samples
Download data: TSV
Series
Accession:
GSE216912
ID:
200216912
12.

miR-193b-5p and miR-374b-5p Are Aberrantly Expressed in Endometriosis and Suppress Endometrial Cell Migration In Vitro

(Submitter supplied) (1) Background: Endometriosis is a prevalent gynecological disease affecting 1 out of 10 women of reproductive age. MicroRNAs (miRNAs) may play a role in endometriosis, though their exact function is unclear. In this study we aimed to identify differentially expressed miRNAs in endometriosis and study their functional role in the disease. (2) Methods: Endometrial tissue was collected from patients with endometriosis (n=15) and healthy controls (n=17). more...
Organism:
Homo sapiens; blank sample
Type:
Non-coding RNA profiling by high throughput sequencing
Platforms:
GPL21697 GPL29497
34 Samples
Download data: TSV
Series
Accession:
GSE275002
ID:
200275002
13.

The control of H. pylori-mediated gastric cancer development and progression through YAP/TAZ signal regulation

(Submitter supplied) Helicobacter pylori(H. pylori), a gastrointestinal pathogen, is known to increase the risk of gastric cancer by activating chronic pro-inflammatory signaling pathways in epithelial cells. Cytotoxin-related protein A (CagA) is known to play an important role in gastric cancer development. CagA has been reported to induce tumors by inducing overexpression of YAP/TAZ, a component of Hippo signaling, and dysregulation of the pathway, thereby promoting cell proliferation and resistance to apoptosis. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
9 Samples
Download data: TXT
Series
Accession:
GSE275727
ID:
200275727
14.

HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA+ plasma cells in the GI tract

(Submitter supplied) Gastrointestinal (GI) B cells and plasma cells (PCs), critical to mucosal homeostasis, play an important role in the host response to HIV-1 infection. Here, high resolution mapping of human B cells and PCs from colon and ileum during both viremic and suppressed HIV-1 infection identified a significant reduction in germinal center (GC) B cells and Follicular Dendritic Cells (FDCs) during HIV-1 viremia. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24676 GPL21697
44 Samples
Download data: RDA
Series
Accession:
GSE272807
ID:
200272807
15.

A pattern to rule them all: tracing a human brain map of shared molecular aspects across aging, Alzheimer’s disease and dementia with Lewy bodies

(Submitter supplied) Aging is often characterized by a progressive loss of cognitive abilities due to the onset of different forms of dementia. Among these, Alzheimer’s Disease (AD) and dementia with Lewy bodies (LBD) are the most widespread ones. However, little is known about the common aspects between these conditions and how these aspects can be linked to aging itself. With this work, we aim to identify a molecular fil rouge that could link aging and different dementias in order to possibly highlight strategic targets for novel therapeutical approaches. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
90 Samples
Download data: TXT
Series
Accession:
GSE280268
ID:
200280268
16.

Inhibition of discoidin domain receptor (DDR)-1 with nilotinib alters CSF miRNAs and is associated with reduced inflammation and vascular fibrosis in Alzheimer's Disease

(Submitter supplied) Discoidin Domain Receptor (DDR)-1 is activated by collagen. Nilotinib is a tyrosine kinase inhibitor that is FDAapproved for leukemia and potently inhibits DDR-1. Individuals diagnosed with mild–moderate Alzheimer’s disease (AD) treated with nilotinib (versus placebo) for 12 months showed reduction of amyloid plaque and cerebrospinal fluid (CSF) amyloid, and attenuation of hippocampal volume loss. However, the mechanisms are unclear. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
67 Samples
Download data: XLSX
Series
Accession:
GSE279869
ID:
200279869
17.

Auranofin as a novel anticancer drug for anaplastic thyroid cancer

(Submitter supplied) To explore the functional roles of deregulated genes in thyroid cancer, Gene Ontology Biological Process (GOBP) and KEGG enrichment analyses were conducted on the overlapping upregulated and downregulated mRNAs. The results of the GOBP analysis suggested significant enrichment in extracellular matrix organization, positive regulation of gene expression, and multicellular organism development. The biological pathways in KEGG were mainly enriched in ECM-receptor interactions, amoebiasis, steroid biosynthesis, and focal adhesions
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
8 Samples
Download data: TXT
Series
Accession:
GSE266999
ID:
200266999
18.

BiP/GRP78 is a pro-viral factor for diverse dsDNA viruses that promotes the survival and proliferation of cells upon KSHV infection

(Submitter supplied) The Endoplasmic Reticulum (ER)-resident HSP70 chaperone BiP (HSPA5) plays a crucial role in maintaining and restoring protein folding homeostasis in the ER. BiP’s function is often dysregulated in cancer and virus-infected cells, conferring pro-oncogenic and pro-viral advantages. We explored BiP's functions during infection by the Kaposi's sarcoma-associated herpesvirus (KSHV), an oncogenic gamma-herpesvirus associated with cancers of immunocompromised patients. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21697
14 Samples
Download data: CSV, HTML, RDS
Series
Accession:
GSE280006
ID:
200280006
19.

Cross-talk between enhancers, structural elements and activating transcription factors maintains the 3D architecture and expression of the CFTR gene.

(Submitter supplied) Here we examine the mechanisms by which multiple cis-regulatory elements (CREs) at the CFTR locus coordinate its expression in intestinal epithelial cells. Using CRISPR/Cas9 to remove CREs, individually and in tandem, followed by assays of gene expression and higher-order chromatin structure (4C-seq), we reveal the cross-talk and dependency of two cell-specific intronic enhancers. The results also suggest an internal monitoring mechanism at the locus whereby alternative enhancers may be recruited when the normal sites are lost. more...
Organism:
Homo sapiens
Type:
Other
Platforms:
GPL20301 GPL21697
46 Samples
Download data: BW
Series
Accession:
GSE186272
ID:
200186272
20.

Centralized control of dynamic gene regulatory circuits governs human T cell rest and activation [H3K27ac_CUTnRUN]

(Submitter supplied) The ability of individual cells to maintain a distinct identity and respond to transient environmental signals requires tightly controlled regulation of gene networks. However, how discrete sets of nuclear regulators coordinate dynamic circuits that respond to extracellular cues remains poorly defined. This is prominent in CD4+ T cells, where cells must respond to diverse immunogenic signals to orchestrate effective adaptive immune responses and maintain immune homeostasis. more...
Organism:
Homo sapiens
Type:
Other
Platform:
GPL21697
160 Samples
Download data: BED, BEDGRAPH, CSV
Series
Accession:
GSE244035
ID:
200244035
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=GPL21697[RGSE]|query=5|qty=23|blobid=MCID_672f1a35e6e18526434520ab|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center