GEO DataSets

(Submitter supplied) Regeneration is pervasive among the metazoa, but to vastly varying degrees. Platyhelminthes, Cnidaria, and Echinodermata are examples of phyla whose members are capable of whole-body regeneration (WBR). While planaria and hydra have been exemplary models of this phenomenon, the molecular details of echinoderm WBR are less established. It remains unclear to what degree such a dramatic regenerative capacity is due to the operation of conserved mechanisms and, in particular, whether any of these are involved in a regenerating Deuterostome. more...

Organism:

Patiria miniata

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL23240 GPL22676

18 Samples

Download data: GTF, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Strongylocentrotus purpuratus; Patiria miniata

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL22676 GPL20965

10 Samples

Download data: BED, BEDGRAPH, TXT

(Submitter supplied) Purpose: The Tbrain transcription factor has demonstrated an evolved preference for low-affinity, secondary site binding motifs between the sea star and sea urchin orthologs. We sought to identify targets of sea urchin and sea star orthologs of Tbr. Because less is known about the function of Tbr during sea star development, we used RNA-seq in conjuction with ChIP-seq studies (GEO:xxxx) to determine the targets of sea star Tbr in early development. more...

Organism:

Patiria miniata

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22676

6 Samples

Download data: TXT

(Submitter supplied) Sea stars and sea urchins are model systems for interrogating the types of deep evolutionary changes that have restructured developmental gene regulatory networks (GRNs). While cis regulatory DNA evolution is likely the predominant mechanism of change, it was recently shown that Tbrain, a Tbox transcription factor protein, has evolved a changed preference for a low affinity, secondary binding motif, although the primary, high affinity motif is conserved. more...

Organism:

Patiria miniata; Strongylocentrotus purpuratus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL20965 GPL22676

4 Samples

Download data: BED, BEDGRAPH