GEO DataSets

(Submitter supplied) Methods: RNA-Seq was used to identify differentially expressed genes between wild type strains, ∆rrpA and ∆rrpB mutants at mid-log (~6 hrs) of growth. 11168H wild type, 11168H∆rrpA, 11168H∆rrpB and 11168H∆rrpAB were plated out on BA plates and incubated at 37°C under microaerobic conditions for 6 hrs. RNA was extracted from the pelleted bacteria cells using PureLink™ RNA Mini Kit (Invitrogen), following manufactures protocol. more...

Organism:

Campylobacter jejuni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22824

20 Samples

Download data: CSV, TSV

(Submitter supplied) The symptoms of infectious diarrheal disease are mediated by the interplay between the host and pathogen. Campylobacter jejuni is the leading bacterial cause of diarrhea worldwide due to its near-ubiquitous zoonotic association with poultry. One of the outstanding questions is what factors drive the intestinal inflammation during the development of C. jejuni-mediated disease. Specifically, it is not known the extent to which the bacteria are responsible for the diarrheal symptoms via cell necrosis, or whether there is immune cell recruitment prior to tissue damage. more...

Organism:

Campylobacter jejuni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22824

78 Samples

Download data: CSV

(Submitter supplied) Major foodborne bacterial pathogens, such as Campylobacter jejuni, have devised complex strategies to establish and foster intestinal infections. For more than two decades researchers have used immortalized cell lines derived from human intestinal tissue to dissect C. jejuni-host cell interactions. Known from these studies is that C. jejuni virulence is multifactorial, requiring a coordinated response to produce virulence factors that facilitate the bacterium’s host-cell interactions. more...

Organism:

Campylobacter jejuni

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL22824 GPL25035

12 Samples

Download data: CSV

(Submitter supplied) Bacteria have evolved different mechanisms to catabolize carbon sources from a mixture of nutrients. They first consume their preferred carbon source, before others are used. Regulatory mechanisms adapt the metabolism accordingly to maximize growth and to outcompete other organisms. The human pathogen Campylobacter jejuni is an asaccharolytic Gram-negative bacterium that catabolizes amino acids and organic acids for growth. more...

Organism:

Campylobacter jejuni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22824

6 Samples

Download data: CSV

(Submitter supplied) The generation of an electrical membrane potential (Δψ), the major constituent of the proton motive force (pmf) is crucial for the ATP synthesis, bacterial growth and motility. The pmf drives the rotation of flagella and is vital for the microaerophilic human pathogen Campylobacter jejuni to colonize the mucus layer of the gut of warm-blooded animals. C. jejuni harbors a branched electron transport chain, enabling respiration with different electron donors and acceptors to generate a Δψ. more...

Organism:

Campylobacter jejuni

Type:

Expression profiling by high throughput sequencing

Platform:

GPL22824

3 Samples

Download data: CSV