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Items: 4

1.

p53 activation during ribosome biogenesis regulates normal erythroid differentiation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL22936 GPL18573
26 Samples
Download data: CEL, WIG
Series
Accession:
GSE157210
ID:
200157210

PubMed Similar studies Analyze with GEO2R

2.

p53 activation during ribosome biogenesis regulates normal erythroid differentiation. [expression]

(Submitter supplied) The role of ribosome biogenesis in erythroid development is supported by the recognition of erythroid defects in ribosomopathies in both Diamond-Blackfan anemia and 5q- syndrome. Whether ribosome biogenesis exerts a regulatory function on normal erythroid development is still unknown. In the present study, a detailed characterization of ribosome biogenesis dynamics during human and murine erythropoiesis shows that ribosome biogenesis is abruptly interrupted by the drop of rDNA transcription and the collapse of ribosomal protein neo-synthesis. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL22936
22 Samples
Download data: CEL
Series
Accession:
GSE137951
ID:
200137951

PubMed Similar studies Analyze with GEO2R

3.

miRNA-145 signalling in TFK-1 cells

(Submitter supplied) Gallbladder carcinoma (GBC) is a rare cancer entity in Western Europe and the US with an incidence of less than 3/100.000 and a survival rate <10%. Radical surgery is the only potentially curative treatment option but most patients diagnosed with GBC are not resectable. Thus, there is a great need for the development of new treatment options, including targeted therapy for GBC. To dissect the epigenetic regulation during GBC development, we performed global miRNA profiling of 40 GBC and 8 normal gallbladder tissues. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL22936
6 Samples
Download data: CEL
Series
Accession:
GSE102815
ID:
200102815

PubMed Full text in PMC Similar studies Analyze with GEO2R

4.

Mislocalization of the cell polarity protein Scribble (Scrib) induces SPARC secretion in hepatocellular carcinoma

(Submitter supplied) Cell polarity is crucial for the maintenance of epithelial cell function and its loss may have an im-portant role in the development and progression of cancer. We here show that overexpression and cytoplasmic enrichment of the baso-lateral polarity complex protein Scribble (Scrib) correlates with poor prognosis of hepatocellular cancer (HCC) patients. Expression of the cytoplasmic ScribP305L in hepatocellular cells induces epithelial to mesenchymal transition (EMT) and supports HCC cell invasion in comparison to cells expressing membrane-localized ScribWT. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL22936
9 Samples
Download data: CEL
Series
Accession:
GSE93742
ID:
200093742

PubMed Similar studies Analyze with GEO2R

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