GEO DataSets

(Submitter supplied) Regulatory T cells (Treg) are potent inhibitors of the activation of the immune system. TGFb and PGE2 have been shown to be involved in the induction of regulatory T cells. The transcriptional profile of CD4+ T cells treated with TGFb as well as PGE2 was compared to untreated CD4+CD25- T cells as well as to regulatory T cells in order to determine the relationship of these cells to regulatory T cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

12 Samples

Download data: TXT

(Submitter supplied) VEGF and IL-10 have been shown to play an inhibitory role on CD4+ T cells. Here we investigate the transcriptional expression changes in CD4+ T cells in response to IL-10 and VEGF treatment. The influence of these substances was investigated either immediately after T cell isolation or after previous short-time cultures.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

12 Samples

Download data: TXT

(Submitter supplied) Regulatory T (Treg) cells are involved in self tolerance and suppression of immunity to pathogens or tumours. FOXP3 is essential for Treg cell development and function. However, the FOXP3-dependent molecular mechanisms are not well understood. Here we compare the expression levels in CD4+ as well as Treg cells in reponse to different treatments in order to evaluate the Treg cell specific gene expression profile.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

12 Samples

Download data: TXT

(Submitter supplied) Comparison of the transcriptional profile of CTLA-4 as well as TGFb treated CD4+ T cells with a Treg cell phenotype and Tconv cells. Since CTLA-4 and TGFb have been described as regulatory T cell inducing factors, CD4+ T cells were activated in the presence of CTLA-4 as well as TGFb. The transcriptional profile of these cells was compared to untreated CD4+CD25- T cells as well as to regulatory T cells in order to determine the relationship of these treated cells to regulatory T cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

12 Samples

Download data: TXT

(Submitter supplied) In the literature, several conditions are described that lead to T cell activation. Within this experiment we compared the influence of various T cell activating conditions on the gene expression pattern of CD4+ T cells. T cell stimulation via anti-CD3 was compared to anti-CD3/anti-CD28 as well as to anti-CD3 and IL-2 stimulation.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

10 Samples

Download data: TXT

(Submitter supplied) CD4+ T cells were activated in the presence of PD1. The transcriptional profile was compared to untreated CD4+ T cells as well as to regulatory T cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

12 Samples

Download data: TXT

(Submitter supplied) Regulatory T (Treg) cells are involved in immune homeostasis and prevention of autoimmunity. Treg cells are characterized by the expression of the transcription factor FOXP3. Mutations in FOXP3 cause severe autoimmunity in mice and humans. However, the FOXP3-dependent molecular mechanisms leading to this severe phenotype are not well understood. Here we introduce a genome-wide transcription study of CD4+ T cells under different treatments in comparison to regulatory T cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

11 Samples

Download data: TXT

(Submitter supplied) Regulatory T (Treg) cells are characterized by the forkhead transcription factor FOXP3. Mutations in FOXP3 cause autoimmunity in mice and humans. Here, Treg cells as well as conventional T cells were isolated from B-CLL patients and analyzed by global gene expression analysis in order to identify biological differences in Treg cells of CLL patients.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

12 Samples

Download data: TXT

(Submitter supplied) Regulatory T cells (Treg) are potent inhibitors of the activation of the immune system. Within these experiments we characterize the transcriptional profile of expanded Treg cells subjected to CD3CD28 short-time activation and subpopulations of CD4+ T cells.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by array

4 related Platforms

82 Samples

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(Submitter supplied) Chronic viral infections caused by HIV in humans or LCMV in mice are characterized by immunodeficiency and chronic inflammation. During chronification, T cells progressively lose effector functions, a process associated with immunoregulatory pathways and known as T-cell exhaustion. A link between ‘exhaustive’ T-cell reprogramming and chronic inflammation has not been established. Using a systems biology approach we demonstrate in HIV and LCMV infection that TNF, a prototypical mediator of chronic inflammation, functions upstream of major immunoregulatory pathways in T cells during chronic viral infection. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

21 Samples

Download data: TXT

(Submitter supplied) Analysis of the regulatory architecture of gene expression variation in CD4+ T cells from patients with active RA. We have integrated gene expression with genotyping data in order to identify eQTLs that characterize the gene expression of CD4+ T cells in active RA.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

26 Samples

Download data: TXT

(Submitter supplied) Fetal growth restriction (FGR) develops when fetal nutrient availability is compromised and increases the risk for perinatal complications and predisposes for offspring obesity, diabetes and cardiovascular disease later in life. Emerging evidence implicates changes in placental function in altered fetal growth and the subsequent development of adult disease. The susceptibility for disease in response to an adverse intrauterine environment differs distinctly between boys and girls, with girls typically having better outcomes. more...

Organism:

Homo sapiens; Papio hamadryas

Type:

Expression profiling by array

Platform:

GPL2507

12 Samples

Download data: TXT

(Submitter supplied) This study compared genome-wide expression profiles of individuals with and without Primary Open-Angle Glaucoma (POAG). One POAG case (case #6 with two replicates #10 and #11) carried a Q368X myocilin mutation.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

36 Samples

Download data: TXT

(Submitter supplied) Peripheral blood mononuclear cells (PBMC) were collected from ficoll gradients of whole blood and immediately processed for total RNA and stored at -80oC until use. Blood was from allergic patients at different timepoints pre or post immunotherapy (RIT). Gene expression was compared for the different timepoints.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

13 Samples

Download data: TXT

(Submitter supplied) Esophageal adenocarcinoma (EAC) has become a major concern in Western countries due to rapid rises in incidence coupled with very poor survival rates. One of the key risk factors for the development of this cancer is the presence of Barrett’s esophagus (BE), which is believed to form in response to repeated gastro-esophageal reflux. In this study we performed comparative, genome-wide expression profiling (using Illumina whole-genome Beadarray) on total RNA extracted from esophageal biopsy tissues from individuals with EAC, BE (in the absence of EAC) and those with normal squamous epithelium. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

54 Samples

Download data: TXT

(Submitter supplied) Regulatory T (Treg) cells are involved in self tolerance, immune homeostasis, prevention of autoimmunity, and suppression of immunity to pathogens or tumours. The forkhead transcription factor FOXP3 is essential for Treg cell development and function as mutations in FOXP3 cause severe autoimmunity in mice and humans. However, the FOXP3-dependent molecular mechanisms leading to this severe phenotype are not well understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

149 Samples

Download data: TXT

(Submitter supplied) Background: Development of target specific therapeutics greatly benefits from simultaneous identification of biomarkers to determine aspects of bioactivity, drug safety and efficacy or even treatment outcome. This is particularly important when targeting pleiotropic factors such as the TGFbeta system. TGFbeta has become a prime target for cancer therapeutics since inhibition of TGFbeta signaling simultaneously attacks the tumor and its microenvironment. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL2507

22 Samples

Download data: TXT

(Submitter supplied) Muscle mass and strength reduce during ageing with a steeper decline in women around the age of 50, which suggests that the menopausal transition is one of the mechanisms for age-induced neuromuscular deteriorations. At the moment, there is no clear explanation for the decline in muscle properties although both physical exercise and maintaining near premenopausal estrogen levels by hormonal replacement have been helpful in their preservation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL2700 GPL2507

60 Samples

Download data: TXT

(Submitter supplied) Dupuytren's contracture (DC) is the most common inherited connective tissue disease of humans and is hypothesized to be associated with aberrant wound healing of the palmar fascia. Fibroblasts and myofibroblasts are believed to play an important role in the genesis of DC and the fibroproliferation and contraction that are hallmarks of this disease. This study compares the gene expression profiles of fibroblasts isolated from DC patients and controls in an attempt to identify key genes whose regulation might be significantly altered in fibroblasts found within the palmar fascia of Dupuytren's patients. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL10301 GPL2507

24 Samples

Download data: XLS