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Items: 1 to 20 of 134

1.

HuR coordinates systemic aging through platelet infiltration

(Submitter supplied) Aging involves morphological and functional changes across different organs, but how these changes are linked among the different organs remains to be elucidated. Here, we uncover a central role of platelets in sys temic aging. In aged mice, the levels of platelet secreted pro inflammatory factors (PSPF) increased greatly in the serum and platelets, leading to a diffuse increase of platelet infiltration in brain, liver, lung, kidney, and aortic root. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
18 Samples
Download data: MTX, TSV
Series
Accession:
GSE281572
ID:
200281572

2.

Transcription factor EB affects the thrombospondin-1 /focal adhesion pathway and inhibits cardiac fibroblast transformation following early acute myocardial infarction

(Submitter supplied) Acute myocardial infarction (AMI) is currently the most common cause of fibrosis in the heart and has been reported to be closely associated with heart failure (HF). The transformation of cardiac fibroblasts (CFs) into myofibroblasts is key to the process of cardiac fibrosis, where CFs serve as the main effector cells. Accumulating evidence suggests that focal adhesions (FAs) regulate the transformation of CFs. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
6 Samples
Download data: TXT
Series
Accession:
GSE280395
ID:
200280395

3.

Phytic acid improves the skin barrier function in murine models of atopic dermatitis through skin microbiota‑derived indole-3-propionic acid

(Submitter supplied) To explore the specific mechanism of phytic acid improving atopic dermatitis，we then and RNA-seq analysis to investigate whether phytic acid improves AD by affecting tryptophan metabolism
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
8 Samples
Download data: TXT
Series
Accession:
GSE270699
ID:
200270699

4.

Non-classical action of Ku70 promotes Treg suppressive function through a FOXP3-dependent mechanism in lung adenocarcinoma

(Submitter supplied) To explore the role of Ku70 in Treg cell biology, we isolated conventional T cells (Tconv) and regulatory T cells (Treg) from Foxp3Yfp-cre mice and performed Ku70 ChIP-seq. Furthermore, to investigate the impact of Ku70 deficiency on Foxp3 binding patterns, we sorted Treg cells from Foxp3Cre (WT) and Xrcc6fl/fl;Foxp3Cre (KO) mice and conducted Foxp3 ChIP-seq. These analyses revealed that Ku70 forms a complex with FOXP3, which supports FOXP3 transcriptional activity.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL28330
12 Samples
Download data: BW, NARROWPEAK
Series
Accession:
GSE278950
ID:
200278950

5.

Whole Cancer Cell Vaccine Protects Ovarian Functions in Tumor-bearing Mice through Downregulating CXCL10

(Submitter supplied) Your female patients with cancer will probably become sub-fertile or infertile even though some finally overcome the cancer through various therapies. Cancer immunotherapy is recently emerging as a promising novel therapy against cancer with high malignancy and lethality, but whether or not cancer immunotherapy affect female fertility is rarely known. In the present study, we employed MCA205 cells-xenografted B6 mice as model to investigate whether two popular immunotherapies, PD-1 monoclonal antibody (PD-1) and whole cancer cell vaccine (WCA), affect ovarian function. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
12 Samples
Download data: TXT
Series
Accession:
GSE248829
ID:
200248829

6.

VIRMA-mediated m6A modification regulates forebrain formation through facilitating ribosome biogenesis

(Submitter supplied) N6-methyladenosine (m6A) modification plays crucial roles in tissue development and homeostasis. However, the mechanisms underlying cellular adaptation of m6A modification and their impact on protein synthesis machinery remain unclear. VIRMA, the largest and evolutionarily conserved core of the m6A methyltransferase complex, is highly expressed in the embryonic brain and various cancers. Here, we demonstrate that VIRMA-mediated m6A modification is essential for active ribosome biogenesis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
24 Samples
Download data: XLSX
Series
Accession:
GSE279759
ID:
200279759

7.

Genome of mouse ES cells is organized as nucleosome wrapping domains

(Submitter supplied) In this research, we investigated the wrapping length of DNA on nucleosomes across the whole genome using wrapping-seq. We discovered that the mouse genome chromatin forms nucleosome wrapping domains (NRDs). NRDs are conserved from flies to human cells. Additionally, our study found that the degree of nucleosome wrapping decreases and matures after DNA replication. Moreover, the degree of nucleosome wrapping is associated with the transcriptional status of genes. more...
Organism:
Mus musculus
Type:
Other; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL28330
39 Samples
Download data: BED, BEDGRAPH, BW, XLSX
Series
Accession:
GSE243091
ID:
200243091

8.

Mouse Gata1 3’UTR modulates Gata1 levels to affect erythropoiesis

(Submitter supplied) The 3' untranslated region (3'UTR) of mRNA plays several important roles in post-transcriptional gene regulation. Some of its functions include regulating mRNA stability by polyadenylation and microRNAs. However, the overall function of the Gata1 3’UTR in mammals has not been defined. In this study, we used CRISPR/CAS9 technology to knock out the sequence of the mouse Gata1 3’UTR. We found a defect in erythropoiesis in mutant mice, evidenced by macrocytic anemia at the baseline. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
6 Samples
Download data: XLS
Series
Accession:
GSE279985
ID:
200279985

9.

Single-cell RNA sequencing reveals cellular heterogeneity of spinal microglia in neuropathic pain

(Submitter supplied) Recent studies reveal that microglia modulate synaptic transmission by direct synaptic pruning. Microglia reactivation is a crucial mechanism of central sensitization in neuropathic pain, yet the exact changes of microglia during the development of neuropathic pain and its interaction with the spinal inhibitory circuits remains unclear. In this work, single-cell sequencing delineates temporal changes in spinal microglia and identifies a specific type of microglia as the subpopulation mediating synaptic pruning. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
4 Samples
Download data: TAR
Series
Accession:
GSE246288
ID:
200246288

10.

Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice

(Submitter supplied) Dietary restriction (DR) has multiple beneficial effects on health and longevity and can also improve the efficacy of certain therapies. Diets used to instigate DR are diverse and the corresponding response is not uniformly measured. We compared the systemic and liver-specific transcriptional response to intermittent fasting (IF) and commercially available fasting-mimicking diet (FMD) after short and long-term use in C57BL/6J mice. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
9 Samples
Download data: TXT
Series
Accession:
GSE279842
ID:
200279842

11.

SHISA3 reprograms tumor-associated macrophages toward an M1 phenotype and enhances cancer immunotherapy

(Submitter supplied) The main challenge for immune checkpoint blockade (ICB) therapy lies in immunosuppressive tumor microenvironment (TME). Repolarizing M2-like tumor-associated macrophages (TAMs) into inflammatory M1 phenotype is a promising strategy for cancer immunotherapy. Here, we found that the transmembrane protein SHISA3 is induced by DAMPs/PAMPs in macrophages via nuclear factor-κB (NF-κB) transcription factors, and SHISA3 forms complex with HSPA8 to reciprocally activates NF-κB signaling thus maintains M1 polarization of macrophages. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
7 Samples
Download data: TXT
Series
Accession:
GSE255711
ID:
200255711

PubMed Full text in PMC Similar studies

12.

Protocol for detecting m5C RNA modification at single-base resolution using m5C-TAC-seq

(Submitter supplied) Here we report m5C-TAC-seq, a base-resolution sequencing method to directly detect m5C sites without affecting unmodified C. In m5C-seq, we combined TET-mediated oxidation of RNA m5C to f5C with the selective chemical labeling reaction of f5C, enabling both pre-enrichment of m5C-containing RNA and a m5C-to-T transition in reverse transcription. m5C-seq identifies 2,500 sites in the transcriptome of HeLa and 768 sites in the transcriptome-wide of HEK293T. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
2 Samples
Download data: TXT
Series
Accession:
GSE278327
ID:
200278327

13.

Genetic Recording of Transient Endothelial Activation in Distinct Alveolar Capillary Cells during Pulmonary Fibrosis

(Submitter supplied) Endothelial to mesenchymal transition (EndoMT) is essential for embryonic development. However, the contribution of ECs to fibroblasts through EndoMT remains highly controversial in adult pathological conditions. Here, our dual-recombinase genetic system precisely captured extensive mesenchymal gene activation events of alveolar capillary cells in chronic TAC-induced pulmonary hypertension and fibrosis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
4 Samples
Download data: TXT
Series
Accession:
GSE277471
ID:
200277471

14.

c-Myc alone is enough to reprogram fibroblasts into functional macrophages [scRNA-seq]

(Submitter supplied) Background Cell therapy based on macrophages is promising in solid tumors, but effective acquisition of macrophages is a challenge. Induced pluripotent stem cell (iPSC)-induced macrophages are a good source but are time-consuming and costly. Macrophages derived from somatic cells by reprogramming technologies have the potential to enable the development of cell-based therapies for numerous malignant diseases. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
2 Samples
Download data: MTX, TSV
Series
Accession:
GSE275457
ID:
200275457

PubMed Full text in PMC Similar studies

15.

IL-8 drives the differentiation of CD74high neutrophils to activate anti-tumor immunity and attenuate NSCLC progression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platforms:
GPL24247 GPL28330
5 Samples
Download data: MTX, TSV
Series
Accession:
GSE252461
ID:
200252461

16.

IL-8 drives the differentiation of CD74high neutrophils to activate anti-tumor immunity and attenuate NSCLC progression [I]

(Submitter supplied) Neutrophils infiltrated in the tumor microenvironment (TME) are heterogeneous populations associated with the prognosis of cancer and cancer immunotherapy. However, the plasticity and function of heterogeneous neutrophils in the TME of non-small cell lung cancer (NSCLC) remain poorly understood. Here, we show that neutrophils produce high levels of IL-8 which induce the differentiation of CD74highSiglecFlow neutrophils and suppress the generation of CD74lowSiglecFhigh neutrophils in the TME of IL-8-humanized (IL8-hu) KrasLSL-G12DTp53fl/fl (KP) and EGFRT790M/Del-Exon19 (EGFRTD) NSCLC mouse models. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
3 Samples
Download data: XLSX
Series
Accession:
GSE250409
ID:
200250409

17.

Integration of transcriptomics and proteomics uncovers novel targets underlying the protective effects of Nrf2 knockout in HEI-OC1 cells

(Submitter supplied) Cisplatin, a utilized anticancer drug in clinical practice, induces sensorineural hearing loss (SNHL) in patients. However, the precise mechanism underlying cisplatin-associated ototoxicity remains unknown. HEI-OC1 cells are immortalized cells derived from the organs of Corti mice and nuclear factor erythroid 2-related factor 2 （Nrf2） knockout (KO) significantly enhances cisplatin resistance in these cells. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
6 Samples
Download data: TXT
Series
Accession:
GSE268900
ID:
200268900

18.

Premature aging effects on COVID-19 pathogenesis: new insights from mouse models

(Submitter supplied) Aging is identified as a significant risk factor for severe coronavirus disease-2019 (COVID-19), often resulting in profound lung damage and mortality. Yet, the biological relationship between aging, aging-related comorbidities, and COVID-19 remains incompletely understood. This study aimed to elucidate the age-related COVID19 pathogenesis using a Hutchinson-Gilford progeria syndrome (HGPS) mouse model with humanized ACE2 receptors. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
42 Samples
Download data: CSV
Series
Accession:
GSE264189
ID:
200264189

PubMed Full text in PMC Similar studies

19.

Astrocyte-Derived Clusterin Disrupts Glial Physiology to Obstruct Remyelination in Mouse Models of Demyelinating Diseases

(Submitter supplied) Multiple sclerosis (MS) is a debilitating demyelinating disease characterized by remyelination failure attributed to inadequate oligodendrocyte precursor cells (OPCs) differentiation and aberrant astrogliosis. A comprehensive cell atlas reanalysis of clinical specimens brings to light heightened clusterin (CLU) expression in a specific astrocyte subtype links to active lesions in MS patients. Our investigation reveals elevated astrocytic CLU levels in both active lesions of patient tissues and female murine MS models. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
18 Samples
Download data: TXT
Series
Accession:
GSE275514
ID:
200275514

PubMed Full text in PMC Similar studies

20.

AS-exos exacerbates microglial ferroptosis-driven neuroinflammation

(Submitter supplied) Experimental atherosclerosis was established by feeding Apoe KO mice a Western, high-fat diet for 12 weeks and experimental cerebral ischemia was established by middle cerebral artery occlusion. RNA-seq was perfomed to investigate the potential gene regulation of AS (LAA)-exo-dependent changes of microglia.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL28330
16 Samples
Download data: CSV, TXT
Series
Accession:
GSE248793
ID:
200248793

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