GPL30305[RGSE] - GEO DataSets

Select item 2002740521.

Successful eculizumab-based desensitization in ABO-incompatible living donor kidney transplantation and its molecular phenotypes

(Submitter supplied) Background: Plasmapheresis/rituximab-based desensitization therapy has successfully reduced anti-ABO antibody levels and suppressed antibody-mediated rejection (AMR) in ABO-incompatible (ABOi) kidney transplantation (KT). However, high titers of anti-ABO antibodies in some patients are refractory to standard desensitization, leading to loss of KT opportunities or AMR. Methods: Eculizumab-based desensitization was used to rescue high-titer ABOi KT patients refractory to plasmapheresis/rituximab-based desensitization. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL30305
12 Samples

Download data: RCC

Series

Accession:: GSE274052

ID:: 200274052

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Select item 2002407782.

Transciptomic signature of chronic antibody-mediated kidney rejection traited by extracorporeal photopheresis

(Submitter supplied) Background: The benefit of extracorporeal photopheresis on the course of kidney transplant rejection is unknown. The aim of our study was to investigate the variations in transcriptomics on graft biopsies when extracorporeal photopheresis was used to treat chronic humoral rejection after kidney transplantation. Methods: we retrospectively analyzed the mRNA expression of 770 genes of interest in graft biopsies performed before and after treatment. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL30305
16 Samples

Download data: RCC, TXT

Series

Accession:: GSE240778

ID:: 200240778

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002121603.

Gene expression data of formalin-fixed-paraffin-embedded (FFPE) renal biopsy tissue assessed with Banff Human Organ Transplant (B-HOT) gene panel assay on NanoString nCounter®

(Submitter supplied) Development and validation of a multi-class molecular model for differential diagnosis of renal allograft rejection, built upon gene expression data from the B-HOT gene panel in a large and diverse cohort of diagnostic FFPE renal biopsies.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL30305
1395 Samples

Download data: RCC

Series

Accession:: GSE212160

ID:: 200212160

Select item 2002429844.

Transcriptomic profiling of transplant glomerulopathy to reveal a novel T-cell dominant subclass

(Submitter supplied) Kidney transplant biopsies showing transplant glomerulopathy (cg > 0) and microvascular inflammation (MVI) in the absence of C4d staining and DSAs do not fulfill the criteria for chronic active antibody-mediated rejection (CA-AMR) diagnosis or any other Banff category. In this multicenter intercontinental study including 36 cases, we compared, among other types of data, the transcriptomic profiles of 14 KTx biopsies classified as cg+MVI DSA-/C4d- with 22 classified as CA-AMR DSA+/C4d+ through novel transcriptomic analysis using the NanoString B-HOT panel. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL30305
35 Samples

Download data: RCC, TXT

Series

Accession:: GSE242984

ID:: 200242984

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Select item 2002009885.

Immune and epithelial determinants of age-related risk and alveolar injury in fatal COVID-19

(Submitter supplied) Respiratory failure in COVID-19 is characterized by widespread disruption of the lung’s alveolar gas exchange interface. To elucidate determinants of alveolar lung damage, we performed epithelial and immune cell profiling in lungs from 24 COVID-19 autopsies and 43 uninfected organ donors ages 18-92 years. We found marked loss of type 2 alveolar epithelial (T2AE) cells and increased peri-alveolar lymphocyte cytotoxicity in all fatal COVID-19 cases, even at early stages before typical patterns of acute lung injury are histologically apparent. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL30305
24 Samples

Download data: RCC

Series

Accession:: GSE200988

ID:: 200200988

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001973046.

Differential expressed genes in biopsies from discarded human kidneys after one hour of normothermic perfusion

(Submitter supplied) Nanostring nCounter Organ Transplant Panel data on 4 cortex biopsies from discarded human kidneys analysing the differential expressed genes after one hour of normothermic perfusion

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL30305
8 Samples

Download data: TXT

Series

Accession:: GSE197304

ID:: 200197304

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001788437.

Differential expression of Organ Transplant rejection related genes in Cp40 treated nonhuman primates

(Submitter supplied) Animals responded to Cp40 treatment (Late Rejector) showed a distinct pattern of gene expression compared to animals who did not respond (Early Rejector).

Organism:: Macaca mulatta; Homo sapiens

Type:: Expression profiling by array

Platform:: GPL30305
6 Samples

Download data: CSV, TXT

Series

Accession:: GSE178843

ID:: 200178843

PubMed Full text in PMC Similar studies Analyze with GEO2R

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