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Items: 4

1.

Anti-HIV-1 CAR-T cells armed with autogenic broadly neutralizing antibody and follicle-homing receptor CXCR5 ar effective against different HIV-1 clades and reduce viral reservoir in HIV-1-infected individuals

(Submitter supplied) Chimeric antigen receptor T (CAR-T) cells, long proposed for HIV-1 treatment, has yet to achieve desirable therapeutic efficacy. In our study, M10 CAR-T cells were used for treating 18 HIV-1 patients via a regimen combining two M10 infusions and repeat chidamide stimulation for HIV reservoir activation. Consequently, 74.3% of M10 infusions resulted in significant suppression of viral rebound (averaging 77.4% decline), with 10 patients showing persistently reduced cell-associated HIV-1 RNA levels (averaging > 1.15 log10) over the 150-day observation period. more...
Organism:
Human immunodeficiency virus 1
Type:
Other
Platforms:
GPL32911 GPL32910
26 Samples
Download data: FA, TXT
Series
Accession:
GSE220111
ID:
200220111
2.

sequel (Human immunodeficiency virus 1)

Organism:
Human immunodeficiency virus 1
1 Series
2 Samples
Download data
Platform
Accession:
GPL32911
ID:
100032911
3.

TD008_after

Organism:
Human immunodeficiency virus 1
Source name:
peripheral blood
Platform:
GPL32911
Series:
GSE220111
Download data: FA, TXT
Sample
Accession:
GSM6788549
ID:
306788549
4.

TD008_before

Organism:
Human immunodeficiency virus 1
Source name:
peripheral blood
Platform:
GPL32911
Series:
GSE220111
Download data: FA, TXT
Sample
Accession:
GSM6788548
ID:
306788548
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db=gds|term=GPL32911[Accession]|query=1|qty=2|blobid=MCID_666fb7aa909a3d46add10540|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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