GEO DataSets

(Submitter supplied) A new safety testing paradigm that relies on gene expression biomarker panels was developed that can easily and quickly identify dose-dependent drug-induced injuries across a number of different tissues in rats prior to drug candidate selection. The resource-sparing approach has yielded positive impact on early compound de-risking, enabling drug advancement in a cost-effective manner while reducing later probability of attrition. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL15569 GPL3631

222 Samples

Download data: TXT

(Submitter supplied) This program addresses the gene signature associated with brain (cortex) in the tMCAO rat model for stroke.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3631

8 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

9 related Platforms

115 Samples

Download data: CEL

(Submitter supplied) In rodents, treatment with peroxisome proliferator-activated receptor alpha (PPARalpha) agonists results in peroxisome proliferation, hepatocellular hypertrophy and hepatomegaly. Drugs in the fibrate class of PPARalpha agonists have also been reported to produce rare skeletal muscle toxicity. Although target-driven hepatic effects of PPARalpha treatment have been extensively studied, a characterization of the transcriptional effects of this nuclear receptor/transcription factor on skeletal muscle responses has not been reported. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3631

484 Samples

Download data

(Submitter supplied) Oligonucleotide array on glass. Contains 60-mer probes (60-mer). Protocol: see manufacturer's web site

Organism:

Rattus norvegicus

4 Series

507 Samples

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