GPL51[RGSE] - GEO DataSets

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Items: 3

Select item 2000033581.

DNA damage responses and Mec1p

(Submitter supplied) Eukaryotic cells respond to DNA damage by arresting the cell cycle and modulating gene expression to ensure efficient DNA repair. The human ATR kinase and its homolog in yeast, MEC1, play central roles in transducing the damage signal. To characterize the role of the Mec1 pathway in modulating the cellular response to DNA damage, we used DNA microarrays to observe genomic expression in Saccharomyces cerevisiae responding to two different DNA-damaging agents. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

6 related Platforms
53 Samples

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Accession:: GSE3358

ID:: 200003358

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000031822.

Two yeast forkhead genes regulate the cell cycle and pseudohyphal growth

(Submitter supplied) There are about 800 genes in Saccharomyces cerevisiae whose transcription is cell-cycle regulated. Some of these form clusters of co-regulated genes. The 'CLB2' cluster contains 33 genes whose transcription peaks early in mitosis, including CLB1, CLB2, SWI5, ACE2, CDC5, CDC20 and other genes important for mitosis. Here we find that the genes in this cluster lose their cell cycle regulation in a mutant that lacks two forkhead transcription factors, Fkh1 and Fkh2. more...

Organism:: Saccharomyces cerevisiae

Type:: Expression profiling by array

Platforms:: GPL51 GPL2650
26 Samples

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Accession:: GSE3182

ID:: 200003182

Select item 2000000183.

Yeast Stress Response

(Submitter supplied) We explored genomic expression patterns in the yeast Saccharomyces cerevisiae responding to diverse environmental transitions. DNA microarrays were used to measure changes in transcript levels over time for almost every yeast gene, as cells responded to temperature shocks, hydrogen peroxide, the superoxide-generating drug menadione, the sulfhydryl-oxidizing agent diamide, the disulfide-reducing agent dithiothreitol, hyper- and hypo-osmotic shock, amino acid starvation, nitrogen source depletion, and progression into stationary phase. more...