GEO DataSets

(Submitter supplied) Camk2-mutPolg mouse carries the transgene of mutated polymerase gamma under Camk2 promoter. By the mutation, polymerase gamma lost its proof-reading activity, and thus tg mouse accumulates deletions and mutations in mitochondrial DNA in neurons. This mouse showed behavioral alterations similar to mood disorders. To examine the epigenetic status in the brain cells, we have performed promoter-wide DNA methylation analysis in neurons and nonneurons of the tg mouse.

Organism:

Mus musculus

Type:

Methylation profiling by array

Platform:

GPL5811

26 Samples

Download data: CEL, MAT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Methylation profiling by genome tiling array

Platforms:

GPL5811 GPL6246

24 Samples

Download data: CEL, CHP, TXT

(Submitter supplied) The differential DNA methylation in hepatocytes was compared between the KK.Cg-Ay/J mice and the KK-a/a mice, corresponding to the Diabetic strain and the wild-type known as control. The methylation microarrays were used to support gene expression for screening the candidates susceptibility to the pathogenesis of Type-2 Diabetes in the pre-development, early and development stages, corresponding to the 6, 16 and 42 weeks old. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL5811

12 Samples

Download data: CEL, CHP, TXT, XLSX

(Submitter supplied) Genome-wide binding of Nkx2-5

Organism:

Mus musculus

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL6246 GPL5811

15 Samples

Download data: BAR, BED, CEL, CHP

(Submitter supplied) The Mouse Promoter Array is designed for chromatin immunoprecipitation (ChIP) experiments. Sequences used in the design of the Mouse Promoter array were selected from NCBI human genome assembly (Build 34). Repetitive elements were removed by RepeatMasker.

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL5811

12 Samples

Download data: CEL, XLSX

(Submitter supplied) Aberrant DNA mehylation expression has been related to diethylstilbestrol exposure, but little is known about effect of diethylstilbestrol exposure on DNA mehylation in male reproductive system. To identify DNA mehylation varied in GC2 cells treated with DMSO and diethylstilbestrol, we performed Gene promoter methylation using an Affymetrix Mouse Promoter 1.0R Array to analysis different DNA methylation pattern.

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL5811

2 Samples

Download data: CEL, TXT

(Submitter supplied) BACKGROUND: Epigenetic processes enable the environment to modulate gene transcription during fetal development, ultimately leading to stable phenotypic changes throughout the lifespan. There is a relatively high prevalence of altered sleep patterns during late gestation, especially obstructive sleep apnea (OSA). Intermittent hypoxia (IH) is a hallmark of OSA caused by periodic obstructions of the upper airway, which occurs along with sleep fragmentation (SF). more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL5811

16 Samples

Download data: CEL, TXT

(Submitter supplied) Recent epidemiological studies suggest that hyponutritional stress during fetal period increase risks of adult-onset diseases, such as type 2 diabetes and mental diseases. Rodent models have demonstrated that hyponutrition during pregnancy alters epigenetic status of neuronal genes in the fetal brains; this implicate fatal environment contributes to susceptibility to mental disorders. However, in these studies, progenies were generated with natural mating and effects of hyponutrition during egg formation have not been eliminated. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array; Expression profiling by array

Platforms:

GPL5811 GPL11202

23 Samples

Download data: BAR, CEL, TXT

(Submitter supplied) Aberrant DNA methylation expression has been related to diethylstilbestrol exposure, but little is known about effect of diethylstilbestrol exposure on DNA methylation in male reproductive system. To identify DNA methylation varied in GC2 cells treated with DMSO and diethylstilbestrol, we performed Gene promoter methylation using an Affymetrix Mouse Promoter 1.0R Array to analysis different DNA methylation pattern.

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL5811

2 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL5811 GPL6246

12 Samples

Download data: CEL, TXT

(Submitter supplied) The upstream stimulating factors (USFs) USF1 and USF2 are ubiquitously expressed transcription factors characterized by a conserved basic helix-loop-helix leucine zipper DNA-binding domain. They form homo- or heterodimers and recognize E-box motifs to modulate gene expression. They are known to regulate diverse cellular functions including the cell cycle, immune response and glucose-lipid metabolism, but their roles in neuronal cells remain to be clarified. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5811

6 Samples

Download data: CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

9 related Platforms

37 Samples

Download data: CEL

(Submitter supplied) Immunological memory is generally thought to be mediated exclusively by lymphocytes such as memory T and B cells. However, enhanced innate immune responses caused by a previous infection increase protection against reinfection suggesting the presence of innate immunological memory. Here, we describe 3,811 ATF7 binding sites in mouse peritoneal macrophages, and 95% of the ATF7 signals in wild-type macrophages are lost in ATF7 knockout macrophages. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by genome tiling array

8 related Platforms

9 Samples

Download data: BED, CEL

(Submitter supplied) NKX2-5 is a homeodomain transcription factor that plays a central role in the cardiac gene regulatory network, and is commonly mutated in human congenital heart disease. Here, we take a functional genomics approach to congenital heart disease mechanism. We used DamID to establish a robust set of target genes for both wild type NKX2-5 and a mutation lacking the homeodomain (NKX2-5delHD), the latter to model loss-of-function in gene regulatory network. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5811

10 Samples

Download data: BED, CEL, COD

(Submitter supplied) Background: Late gestational sleep fragmentation (LG-SF) is one of the major perturbations associated with sleep apnea and other sleep disorders during pregnancy. Objectives: To investigate the effects of late LG-SF on the epigenome of visceral white adipose tissue (VWAT) in the offspring. Methods: Time-pregnant mice were exposed to LG-SF or control sleep (LG-SC) conditions during the last 6 days of gestation. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL5811

16 Samples

Download data: CEL, TXT

(Submitter supplied) Intermittent hypoxia (IH) is a hallmark of obstructive sleep apnea (OSA), which has been proposed as the major determinant of processes involving tumor invasion and metastasis. To study whether circulating DNA (cirDNA) in blood plasma reflects the changes that the tumor cells undergo under IH conditions, we used a xenografted murine model. Mice engrafted with TC1 epithelial lung and controls were exposed to IH or room air (RA) conditions. more...

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL5811

6 Samples

Download data: CEL, CSV, TXT

(Submitter supplied) The serotonin transporter (5-HTT) gene-linked polymorphic region has been suggested to play a modulatory role in mediating the effects of early-life stress on psychopathology rendering carriers of the low-expression short (s)-allele more vulnerable to environmental adversity in later life. Here we analyzed the effects of prenatal stress (PS), 5-Htt genotype, and an interactin of both on DNA methylation in the hippocampi of female C57BL/6 mice. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL5811

22 Samples

Download data: BED, BEDGRAPH, CEL

(Submitter supplied) To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest that these retained histones provide epigenetic information that regulates expression of a subset of genes involved in embryo development after fertilization. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5811

19 Samples

Download data: BEDGRAPH, CEL, TXT

(Submitter supplied) To achieve the extreme nuclear condensation necessary for sperm function, most histones are replaced with protamines during spermiogenesis in mammals. Mature sperm retain only a small fraction of nucleosomes, which are, in part, enriched on gene regulatory sequences, and recent findings suggest that these retained histones provide epigenetic information that regulates expression of a subset of genes involved in embryo development after fertilization. more...

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by genome tiling array

Platform:

GPL5811

25 Samples

Download data: BEDGRAPH, CEL, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Genome binding/occupancy profiling by genome tiling array

Platforms:

GPL6246 GPL5811

79 Samples

Download data: BEDGRAPH, CEL