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Items: 11

1.

Differences in genome-wide gene expression response in PBMCs between young and old men upon caloric restriction

(Submitter supplied) Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different non-human organisms. Only a limited number of CR studies have been performed in humans, and results put CR as a beneficial tool to decrease risk factors in several age-related diseases. The question remains at what age CR should be implemented to be most effective with respect to healthy aging. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
38 Samples
Download data: CEL
Series
Accession:
GSE63117
ID:
200063117
2.

Expression data from HeLa cells treated with tocotrienols

(Submitter supplied) We used microarrays to investigate the pattern of gene expression induced by tocotrienols treatment in HeLA cells Our study demonstrates that treatment with γ- and δ-T3 is associated to specific Ca-dependent signals
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
11 Samples
Download data: CEL
Series
Accession:
GSE48668
ID:
200048668
3.

Differential expression profiles of human primary endothelial cells (HUVECs) from umbilical cords of Gestational Diabetic mothers

(Submitter supplied) Primary endothelial cells from umbilical cord vein (HUVEC) obtained at delivery from gestational diabetic (GD) women, represent an expedient model for the study of the effects of chronic HG in vivo. In fetal tissues genome-wide epigenetic changes are likely to occur with specific long term and even trans-generational effects. We have utilized this model to study the effects of chronic hyperglycemia on the transcriptome and to verify the presence of specific epigenetic changes associated to chronic HG in vascular cells.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
6 Samples
Download data: CEL
Series
Accession:
GSE49524
ID:
200049524
4.

Effects of a diet high in monounsaturated fat and a full Mediterranean diet on PBMC whole genome gene expression and plasma proteins

(Submitter supplied) This study aimed to identify the effects of replacement of saturated fat (SFA) by monunsaturated fat (MUFA) in a western-type diet and the effects of a full Mediterranean (MED) diet on whole genome PBMC gene expression and plasma protein profiles. Abdominally overweight subjects were randomized to a 8 wk completely controlled SFA-rich diet, a SFA-by-MUFA-replaced diet (MUFA diet) or a MED diet. Concentrations of 124 plasma proteins and PBMCs whole genome transcriptional profiles were assessed. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
98 Samples
Download data: CEL
Series
Accession:
GSE30509
ID:
200030509
5.

Early life growth and gene profile changes during childhood

(Submitter supplied) To compare early life exposures to see if they are associated with persistent molecular changes at the transcriptional level. Subjects were drawn from the Newcastle Pre-Term Birth Growth Study. A randomised, controlled trial to look at the effect on growth of dietary manipulation after hospital discharge.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
23 Samples
Download data: CEL
Series
Accession:
GSE22013
ID:
200022013
6.

Expression data from human omental and subcutaneous adipose tissue taken from volunteers undergoing bariatric surgery

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platforms:
GPL570 GPL7020
26 Samples
Download data: CEL
Series
Accession:
GSE29411
ID:
200029411
7.

Subcutaneous and omental white adipose tissue biopsies analysed from five obese patients

(Submitter supplied) The objective was to characterize differences in the secretome of human omental compared with subcutaneous adipose tissue using global gene expression profiling. Gene expression was measured using Affymetrix microarrays in subcutaneous and omental adipose tissue (n=5 independent subjects; 10 arrays). Predictive bioinformatic algorithms were employed to identify those differentially expressed genes that code for secreted proteins and to identify common pathways between these proteins. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
20 Samples
Download data: CEL
Series
Accession:
GSE29409
ID:
200029409
8.

Transcriptomic response to variation in habitual n-3 polyunsaturated fatty acid intake

(Submitter supplied) Analysis of variation in subcutaneous adipose tissue gene expression in response to dietary intake of n-3 polyunsaturated fatty acids, as assessed in a cohot of individuals with metabolic syndrome. Outcomes from this study provide insight on molecular details of dietary effects on gene expression and metabolic health.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
17 Samples
Download data: CEL
Series
Accession:
GSE28070
ID:
200028070
9.

Effects of Bifidobacterium bifidum PRL2010 on gene expression in intestinal epithelial cells

(Submitter supplied) Analysis of gene expression in Caco-2 intestinal epithelial cells stimulated with Bifidobacterium bifidum PRL2010. We used microarrays to investigate gene expression in intestinal epithelial cells in response to Bifidobacterium bifidum PRL2010, in particular genes involved in mucin pathways.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
8 Samples
Download data: CEL
Series
Accession:
GSE21976
ID:
200021976
10.

Eicosapentaenoic acid improves metabolic switching in human myotubes

(Submitter supplied) Metabolically healthy skeletal muscle is characterized by the ability to switch easily between glucose and fat oxidation, whereas loss of this ability seems to be related to insulin resistance. The aim of this study was to investigate whether different fatty acids (FAs) and the LXR ligand T0901317 affected metabolic switching in human skeletal muscle cells (myotubes). Pretreatment of myotubes with eicosapentaenoic acid (EPA) increased suppressibility, the ability of glucose to suppress FA oxidation, and metabolic flexibility, the ability to increase FA oxidation when changing from “fed” to “fasted” state. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7020
15 Samples
Download data: CEL
Series
Accession:
GSE18589
ID:
200018589
11.

A saturated fatty acid rich diet can induce an 'obese-like' gene expression profile in adipose tissue

(Submitter supplied) We investigated the effect of a saturated (SFA) and a monounsaturated (MUFA) rich diet on insulin sensitivity and adipose tissue gene expression profiles of subjects at risk for metabolic syndrome. A controlled-feeding trial was performed with 20 moderately overweight subjects. Subjects received a SFA-rich or a MUFA-rich diet for 8 weeks. Subcutaneous adipose tissue samples were obtained and insulin sensitivity was measured. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3678
Platform:
GPL7020
40 Samples
Download data: CEL
Series
Accession:
GSE14954
ID:
200014954
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