GSE112244[Accession] - GEO DataSets - NCBI

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Items: 14

Select item 2001122441.

Th1 and T17 activation with and without CB839 treatment

(Submitter supplied) Activated T cells differentiate into functional subsets which require distinct metabolic programs. Glutaminase (GLS) converts glutamine to glutamate to provide substrate for the tricarboxylic acid cycle and epigenetic reactions and here we identify a key role for GLS in T cell activation and specification. Though GLS-deficiency diminished T cell activation, proliferation and impaired differentiation of Th17 cells, loss of GLS also increased Tbet and Interferon-γ expression and CD4 Th1 and CD8 CTL effector cell differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
12 Samples

Download data: TXT

Series

Accession:: GSE112244

ID:: 200112244

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000214932.

Illumina HiSeq 3000 (Mus musculus)

Organism:: Mus musculus

1121 Series
42386 Samples

Platform

Accession:: GPL21493

ID:: 100021493

Select item 3030615603.

Organism:: Mus musculus

Source name:: Th17 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061560

ID:: 303061560

SRA Run Selector

Select item 3030615594.

Organism:: Mus musculus

Source name:: Th17 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061559

ID:: 303061559

SRA Run Selector

Select item 3030615585.

Organism:: Mus musculus

Source name:: Th17 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061558

ID:: 303061558

SRA Run Selector

Select item 3030615576.

Th17 + Vehicle 3

Organism:: Mus musculus

Source name:: Th17 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061557

ID:: 303061557

SRA Run Selector

Select item 3030615567.

Th17 + Vehicle 2

Organism:: Mus musculus

Source name:: Th17 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061556

ID:: 303061556

SRA Run Selector

Select item 3030615558.

Th17 + Vehicle 1

Organism:: Mus musculus

Source name:: Th17 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061555

ID:: 303061555

SRA Run Selector

Select item 3030615549.

Organism:: Mus musculus

Source name:: Th1 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061554

ID:: 303061554

SRA Run Selector

Select item 30306155310.

Organism:: Mus musculus

Source name:: Th1 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061553

ID:: 303061553

SRA Run Selector

Select item 30306155211.

Organism:: Mus musculus

Source name:: Th1 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061552

ID:: 303061552

SRA Run Selector

Select item 30306155112.

Th1 + Vehicle 3

Organism:: Mus musculus

Source name:: Th1 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061551

ID:: 303061551

SRA Run Selector

Select item 30306155013.

Th1 + Vehicle 2

Organism:: Mus musculus

Source name:: Th1 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061550

ID:: 303061550

SRA Run Selector

Select item 30306154914.

Th1 + Vehicle 1

Organism:: Mus musculus

Source name:: Th1 cells

Platform:: GPL21493
Series:: GSE112244

Sample

Accession:: GSM3061549

ID:: 303061549

SRA Run Selector

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