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Items: 6

1.

Transcriptional response of M. tuberculosis to quinazoline-11626252 treatment

(Submitter supplied) We report here lead optimisation efforts of a new series of cytochrome bc1 oxidase inhibitors, the quinazoline derivatives. Four derivatives showed mild to no cytotoxicity as potent in vitro and ex vivo activity in infected THP-1 macrophages against M. tuberculosis. Isolation of resistant mutants to one of the derivatives in M. tuberculosis revealed mutations in both QcrA and QcrB of the cytochrome bc1 oxidase, one of two terminal oxidases of the mycobacterial electron transport chain. more...
Organism:
Mycobacterium tuberculosis
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17879
4 Samples
Download data: CSV, TXT
Series
Accession:
GSE119158
ID:
200119158

SRA Run Selector

2.

Illumina HiSeq 2500 (Mycobacterium tuberculosis)

Organism:
Mycobacterium tuberculosis
35 Series
450 Samples
Download data
Platform
Accession:
GPL17879
ID:
100017879

3.

M. tuberculosis exposed to quinazoline-11626252 at 30x MIC, replicate 2

Organism:
Mycobacterium tuberculosis
Source name:
cell culture
Platform:
GPL17879
Series:
GSE119158
Download data
Sample
Accession:
GSM3359734
ID:
303359734

SRA Run Selector

4.

M. tuberculosis exposed to quinazoline-11626252 at 30x MIC, replicate 1

Organism:
Mycobacterium tuberculosis
Source name:
cell culture
Platform:
GPL17879
Series:
GSE119158
Download data
Sample
Accession:
GSM3359733
ID:
303359733

SRA Run Selector

5.

M. tuberculosis exposed to quinazoline-11626252 at 10x MIC, replicate 2

Organism:
Mycobacterium tuberculosis
Source name:
cell culture
Platform:
GPL17879
Series:
GSE119158
Download data
Sample
Accession:
GSM3359732
ID:
303359732

SRA Run Selector

6.

M. tuberculosis exposed to quinazoline-11626252 at 10x MIC, replicate 1

Organism:
Mycobacterium tuberculosis
Source name:
cell culture
Platform:
GPL17879
Series:
GSE119158
Download data
Sample
Accession:
GSM3359731
ID:
303359731

SRA Run Selector

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db=gds|term=GSE119158[Accession]|query=26|qty=2|blobid=MCID_6733edd85c1af073747d697d|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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