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Items: 7

1.

Restoration of KMT2C in human colorectal cancer cell lines HCT116 and RKO reinforces genome wide H3K4me1 profiles

(Submitter supplied) The histone 3 lysine 4 (H3K4) monomethylase KMT2C is mutated across several cancer types, however the effects of mutations on epigenome organization, gene expression and cell growth are not clear. To study effects of KMT2C expression in CRC cells we restored one allele to wild type KMT2C in the two CRC cell lines RKO and HCT116, which both are homozygous KMT2C c.8390delA mutant. Chromatin was analysed by ChIP-sequencing using the Diagenode iDeal ChIP-seq kit for Histones and the H3K4me1 specific antibody (Abcam ab8895).
Organism:
Homo sapiens
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL11154
5 Samples
Download data: TXT
Series
Accession:
GSE131755
ID:
200131755

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10550 Series
183623 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

HCT116 KMT2C KI2 H3K4me1

Organism:
Homo sapiens
Source name:
Cell culture
Platform:
GPL11154
Series:
GSE131755
Download data: TXT
Sample
Accession:
GSM3815200
ID:
303815200

SRA Run Selector

4.

HCT116 KMT2C KI1 H3K4me1

Organism:
Homo sapiens
Source name:
Cell culture
Platform:
GPL11154
Series:
GSE131755
Download data: TXT
Sample
Accession:
GSM3815199
ID:
303815199

SRA Run Selector

5.

HCT116 parental H3K4me1

Organism:
Homo sapiens
Source name:
Cell culture
Platform:
GPL11154
Series:
GSE131755
Download data: TXT
Sample
Accession:
GSM3815198
ID:
303815198

SRA Run Selector

6.

RKO KMT2C KI2 H3K4me1

Organism:
Homo sapiens
Source name:
Cell culture
Platform:
GPL11154
Series:
GSE131755
Download data: TXT
Sample
Accession:
GSM3815197
ID:
303815197

SRA Run Selector

7.

RKO parental H3K4me1

Organism:
Homo sapiens
Source name:
Cell culture
Platform:
GPL11154
Series:
GSE131755
Download data: TXT
Sample
Accession:
GSM3815196
ID:
303815196

SRA Run Selector

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db=gds|term=GSE131755[Accession]|query=14|qty=2|blobid=MCID_6733f0bb5c1af073747db45f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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