GSE15102[Accession] - GEO DataSets

Select item 2000151021.

Targetting CD24 for treatment of colorectal and pancreatic cancer by monoclonal antibodies or siRNA

(Submitter supplied) CD24 is a potential oncogene reported to be overexpressed in a large variety of human malignancies. We have shown that CD24 is overexpressed in 90% of colorectal tumors at a fairly early stage in the multistep process of carcinogenesis. Anti-CD24 monoclonal antibodies (mAb) induce a significant growth inhibition in colorectal and pancreatic cancer cell lines that express the protein. This study is designed to investigate further the effects of CD24 down-regulation using mAb or small interfering RNA in vitro and in vivo. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS4101
Platform:: GPL571
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE15102

ID:: 200015102

Select item 41012.

Response of pancreatic and colorectal cancer cells to CD24 down-regulation by monoclonal antibody or small interfering RNA

Analysis of HT29 and Colo357 cancer cell lines following treatment with anti-CD24 mAbs, and HT29 cells after expression of 1 or 2 shRNA vectors directed at the CD24 gene. CD24 is overexpressed in a large variety of human malignancies. Results provide insight into the role of CD4 in carcinogenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 5 agent, 2 cell line sets

Platform:: GPL571
Series:: GSE15102
8 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS4101

ID:: 4101

Select item 1000005713.

[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Human Genome U133A 2.0 Array is a single array representing 14,500 well-characterized human genes that can be used to explore human biology and disease processes. more...