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Items: 6

1.

Development, Cryo-EM structure and function of potent monospecific and bispecific monoclonal antibodies that neutralize SARS-CoV-2 and variant B.1.351

(Submitter supplied) The COVID-19 pandemic prompted an unprecedented effort to develop effective countermeasures against SARS-CoV-2. While efficacious vaccines and certain therapeutic monoclonal antibodies are available, here, we report the development, cryo-EM structures and functional analyses of distinct potent monoclonal antibodies (mAbs) that neutralize SARS-CoV-2 and its variant B.1.351. We established a platform for rapid identification of highly potent and specific SARS-CoV-2-neutralizing antibodies by high-throughput B cell receptor single cell sequencing of spike receptor binding domain immunized animals. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
4 Samples
Download data: CSV
Series
Accession:
GSE174635
ID:
200174635
2.

Illumina NovaSeq 6000 (Mus musculus)

Platform
Accession:
GPL24247
ID:
100024247
3.

BALBc-2

Organism:
Mus musculus
Source name:
spleen, draining lymph nodes, and bone marrow
Platform:
GPL24247
Series:
GSE174635
Download data: CSV
Sample
Accession:
GSM5320853
ID:
305320853
4.

BALBc-1

Organism:
Mus musculus
Source name:
spleen, draining lymph nodes, and bone marrow
Platform:
GPL24247
Series:
GSE174635
Download data: CSV
Sample
Accession:
GSM5320852
ID:
305320852
5.

C57-BM

Organism:
Mus musculus
Source name:
bone marrow
Platform:
GPL24247
Series:
GSE174635
Download data: CSV
Sample
Accession:
GSM5320851
ID:
305320851
6.

C57-spleen

Organism:
Mus musculus
Source name:
spleen and draining lymph nodes
Platform:
GPL24247
Series:
GSE174635
Download data: CSV
Sample
Accession:
GSM5320850
ID:
305320850
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Supplemental Content

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