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Items: 1 to 20 of 57

1.

PALI1 Promotes Tumor Growth through Competitive Recruitment of PRC2 to G9A-target Chromatin for Dual Epigenetic Silencing

(Submitter supplied) PALI1 is a newly identified accessory protein of the Polycomb Repressive Complex 2 (PRC2) that catalyzes H3K27 methylation. However, the roles of PALI1 in cancer are yet to be defined. Here we report that PALI1 is upregulated in advanced prostate cancer (PCa) and competes with JARID2 for binding to PRC2 core subunit SUZ12. PALI1 further interacts with the H3K9 methyltransferase G9A, bridging the formation of a unique G9A-PALI1-PRC2 super-complex that occupies a subset of G9A-target genes to mediate dual H3K9/K27 methylation and gene repression. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL20301 GPL15456
54 Samples
Download data: BW
Series
Accession:
GSE175697
ID:
200175697

PubMed Full text in PMC Similar studies

2.

Illumina HiSeq 4000 (Homo sapiens)

Organism:
Homo sapiens
8501 Series
195310 Samples
Download data
Platform
Accession:
GPL20301
ID:
100020301

3.

Illumina HiScanSQ (Homo sapiens)

Organism:
Homo sapiens
122 Series
2006 Samples
Download data
Platform
Accession:
GPL15456
ID:
100015456

4.

shPALI1_SUZ12 ChIP-seq_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541907
ID:
306541907

SRA Run Selector

5.

shPALI1_SUZ12 ChIP-seq_Rep1

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541906
ID:
306541906

SRA Run Selector

6.

pLKO_SUZ12 ChIP-seq

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541905
ID:
306541905

SRA Run Selector

7.

shPALI1_Jarid2_CUT&RUN

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541904
ID:
306541904

SRA Run Selector

8.

pLKO_Jarid2_CUT&RUN

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541903
ID:
306541903

SRA Run Selector

9.

shPALI1_H3K27me3_CUTTag_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541902
ID:
306541902

SRA Run Selector

10.

shPALI1_H3K27me3_CUTTag_Rep1

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541901
ID:
306541901

SRA Run Selector

11.

shPALI1_PALI1 CUT&RUN_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541900
ID:
306541900

SRA Run Selector

12.

shPALI1_PALI1 CUT&RUN_Rep1

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541899
ID:
306541899

SRA Run Selector

13.

shG9a_H3K27me3 CUTTag_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541898
ID:
306541898

SRA Run Selector

14.

shG9a_H3K27me3 CUTTag_Rep1

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541897
ID:
306541897

SRA Run Selector

15.

shG9a_PALI1 CUT&RUN_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541896
ID:
306541896

SRA Run Selector

16.

shG9a_PALI1 CUT&RUN_Rep1

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541895
ID:
306541895

SRA Run Selector

17.

siG9a_G9a ChIP-seq_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541894
ID:
306541894

SRA Run Selector

18.

siG9a_G9a ChIP-seq_Rep1

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541893
ID:
306541893

SRA Run Selector

19.

pLKO_H3K27me3 CUTTag_Rep2

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541892
ID:
306541892

SRA Run Selector

20.

pLKO_H3K27me3 CUTTag_Rep1

Organism:
Homo sapiens
Source name:
Human prostate cancer cells
Platform:
GPL15456
Series:
GSE175697 GSE212625
Download data: BW
Sample
Accession:
GSM6541891
ID:
306541891

SRA Run Selector

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db=gds|term=GSE175697[Accession]|query=8|qty=2|blobid=MCID_673b91cfa56b24050d343d63|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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