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Items: 10

1.

Correcting altered immunological responses in obesity restores efficacy of targeted biologic therapy for inflammatory disease

(Submitter supplied) Decades of work have elucidated cytokine signaling and transcriptional pathways that control T cell differentiation and have led the way to targeted biologic therapies that are effective in a range of autoimmune, allergic, and inflammatory diseases. More recent evidence indicates that obesity and other shifts in systemic metabolism can also influence the function of cells in the immune system, although the mechanisms and possible effects on immunotherapy outcomes remain largely unknown. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21103
8 Samples
Download data: H5, H5AD
Series
Accession:
GSE189476
ID:
200189476
2.

Illumina HiSeq 4000 (Mus musculus)

Platform
Accession:
GPL21103
ID:
100021103
3.

Lesional CD4+ T Cells - Obese PPARg TKO (CD4-Cre PPARg fl/fl) Mice given Rosi HFD

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702417
ID:
305702417
4.

Lesional CD4+ T Cells - Obese Control (wt Bl6) Mice given Rosi HFD

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702416
ID:
305702416
5.

Lesional CD4+ T Cells - Obese PPARg TKO (CD4-Cre PPARg fl/fl) Mice given Control HFD

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702415
ID:
305702415
6.

Lesional CD4+ T Cells - Obese Control (wt Bl6) Mice given Control HFD

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702414
ID:
305702414
7.

Lesional CD4+ T Cells - PPARg TKO (CD4-Cre PPARg fl/fl) Mice - Lean

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702413
ID:
305702413
8.

Lesional CD4+ T Cells - Control (CD4-Cre) Mice - Lean

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702412
ID:
305702412
9.

Lesional CD4+ T Cells - Obese Mice

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702411
ID:
305702411
10.

Lesional CD4+ T Cells - Lean Mice

Organism:
Mus musculus
Source name:
sorted lesional skin CD4+ T cells
Platform:
GPL21103
Series:
GSE189476
Download data: H5
Sample
Accession:
GSM5702410
ID:
305702410
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Supplemental Content

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