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1.

The gene expression profile of CD4 T-cells with STAT3 gain-of-function and loss-of-function mutations

(Submitter supplied) Purpose: Recently discovered activating Interleukin-6 receptor subunit beta (IL6ST, encoding glycoprotein 130 (gp130)) mutations, as well as germline Signal transducer and activator of transcription 3 (STAT3) gain-of-function mutations are associated with multi-organ autoimmunity, severe morbidity, and adverse prognosis, resulting in an unmet medical need. Methods: To decipher the crucial cellular subsets and disease biology associated with STAT3 gain-of-function mutations, we examined the gene expression profile of STAT3 gain-of-function and loss-of-function mutations in unstimulated, IL10- or IL21-stimulated CD4 T cells and compared them to healthy donor cells. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
29 Samples
Download data: TXT
Series
Accession:
GSE198963
ID:
200198963
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

ControlZw_IL21

Organism:
Homo sapiens
Source name:
IL21 stimulated control CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961778
ID:
305961778
4.

ControlZw_Unst

Organism:
Homo sapiens
Source name:
Unstimulated control CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961777
ID:
305961777
5.

ControlAD_IL10

Organism:
Homo sapiens
Source name:
IL10 stimulated control CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961776
ID:
305961776
6.

ControlAD_IL21

Organism:
Homo sapiens
Source name:
IL21 stimulated control CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961775
ID:
305961775
7.

ControlAD_Unst

Organism:
Homo sapiens
Source name:
Unstimulated control CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961774
ID:
305961774
8.

H332L_IL10

Organism:
Homo sapiens
Source name:
IL10 stimulated STAT3-LoF (H332L) CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961773
ID:
305961773
9.

H332L_IL21

Organism:
Homo sapiens
Source name:
IL21 stimulated STAT3-LoF (H332L) CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961772
ID:
305961772
10.

H332L_Unst

Organism:
Homo sapiens
Source name:
Unstimulated STAT3-LoF (H332L) CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961771
ID:
305961771
11.

Q288P_1_1_IL10

Organism:
Homo sapiens
Source name:
IL10 stimulated STAT3-Q288P CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961770
ID:
305961770
12.

Q288P_1_1_IL21

Organism:
Homo sapiens
Source name:
IL21 stimulated STAT3-Q288P CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961769
ID:
305961769
13.

Q288P_1_1_Unst

Organism:
Homo sapiens
Source name:
Unstimulated STAT3-Q288P CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961768
ID:
305961768
14.

Q280P_IL10

Organism:
Homo sapiens
Source name:
IL10 stimulated STAT3-Q280P CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961767
ID:
305961767
15.

Q280P_IL21

Organism:
Homo sapiens
Source name:
IL21 stimulated STAT3-Q280P CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961766
ID:
305961766
16.

Q280P_Unst

Organism:
Homo sapiens
Source name:
Unstimulated STAT3-Q280P CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961765
ID:
305961765
17.

E415L_IL10

Organism:
Homo sapiens
Source name:
IL10 stimulated STAT3-E415L CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961764
ID:
305961764
18.

E415L_IL21

Organism:
Homo sapiens
Source name:
IL21 stimulated STAT3-E415L CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961763
ID:
305961763
19.

E415L_Unst

Organism:
Homo sapiens
Source name:
Unstimulated STAT3-E415L CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961762
ID:
305961762
20.

T716M_IL10

Organism:
Homo sapiens
Source name:
IL10 stimulated STAT3-T716M CD4+ T-cells
Platform:
GPL24676
Series:
GSE198963
Download data: TXT
Sample
Accession:
GSM5961761
ID:
305961761
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Supplemental Content

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