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1.

Integrated Epigenetic and Transcriptional Single-Cell Analysis of t(11;14) Multiple Myeloma and Its BCL2 Dependency

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. The translocation t(11;14) occurs in 20% of multiple myeloma (MM) patients and results in the upregulation of CCND1. Nearly two-thirds of t(11;14) MM cells are BCL2 primed and highly responsive to the oral BCL2 inhibitor venetoclax. While it is evident that this unique sensitivity to venetoclax depends on the BH3-proapoptotic protein priming of BCL2, the biology underlying t(11;14) MM dependency on BCL2 is poorly defined. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL18573
58 Samples
Download data: BED, H5
Series
Accession:
GSE199373
ID:
200199373
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

Patient_1438_Post_Treatment_CNV

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199372 GSE199373
Download data: H5
Sample
Accession:
GSM7040859
ID:
307040859
4.

Patient_P1722_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040858
ID:
307040858
5.

Patient_P1606_Post_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040857
ID:
307040857
6.

Patient_P1395_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040856
ID:
307040856
7.

Patient_P1461_Post_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040855
ID:
307040855
8.

Patient_P1396_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040854
ID:
307040854
9.

Patient_P1809_Post_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040853
ID:
307040853
10.

Patient_P1751_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040852
ID:
307040852
11.

Patient_P1388_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040851
ID:
307040851
12.

Patient_P1680_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040850
ID:
307040850
13.

Patient_P1752_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040849
ID:
307040849
14.

Patient_P1643_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040848
ID:
307040848
15.

Patient_P1345_Post_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040847
ID:
307040847
16.

Patient_P1299_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040846
ID:
307040846
17.

Patient_P1675_Post_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040845
ID:
307040845
18.

Patient_P1608_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040844
ID:
307040844
19.

Patient_P1723_Pre_Treatment_scRNA-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199359 GSE199373
Download data: H5
Sample
Accession:
GSM7040843
ID:
307040843
20.

Patient_P1722_Pre_Treatment_ATAC-seq

Organism:
Homo sapiens
Source name:
Primary CD138+ MM cells
Platform:
GPL18573
Series:
GSE199268 GSE199373
Download data: BED, H5
Sample
Accession:
GSM7040842
ID:
307040842
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Supplemental Content

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