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Items: 6

1.

ACK1/TNK2 Epigenetically Regulates Cell Cycle Program to Promote Breast Cancer Resistance to CDK4/6 inhibitor (RNA-Seq)

(Submitter supplied) Over-activation of oncogenes by aberrant expression of epigenetic modulators, overcoming cell cycle checkpoints and bestowing infinite multiplication potency acts as the mainstay of malignancy. We identified one such non-receptor tyrosine kinase ACK1 as an epigenetic regulator of cell cycle genes governing the G2/M transition of breast cancer cells. ACK1 was found to be over-activated (pY264-ACK1) in most of the breast cancer sub-types, independent of their hormone receptor status, as assessed by the Tissue-microarray analysis of nearly 400 breast cancer patient samples. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
4 Samples
Download data: XLSX
Series
Accession:
GSE203231
ID:
200203231
2.

Illumina NovaSeq 6000 (Homo sapiens)

Platform
Accession:
GPL24676
ID:
100024676
3.

MDA-MB-453_UNT RNA

Organism:
Homo sapiens
Source name:
MDA-MB-453
Platform:
GPL24676
Series:
GSE203231 GSE203232
Download data
Sample
Accession:
GSM6165057
ID:
306165057
4.

MDA-MB-453_dz67

Organism:
Homo sapiens
Source name:
MDA-MB-453
Platform:
GPL24676
Series:
GSE203231 GSE203232
Download data
Sample
Accession:
GSM6165056
ID:
306165056
5.

HCC-1395_UNT

Organism:
Homo sapiens
Source name:
HCC-1395
Platform:
GPL24676
Series:
GSE203231 GSE203232
Download data
Sample
Accession:
GSM6165055
ID:
306165055
6.

HCC-1395_dz67

Organism:
Homo sapiens
Source name:
HCC-1395
Platform:
GPL24676
Series:
GSE203231 GSE203232
Download data
Sample
Accession:
GSM6165054
ID:
306165054
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Supplemental Content

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