GSE216091[Accession] - GEO DataSets - NCBI

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Select item 2002160911.

Targeting MYC effector functions in pancreatic cancer by inhibiting the ATPase RUVBL1/2 (Screen)

(Submitter supplied) Objective: The hallmark oncogene MYC drives the progression of most tumorstumours, but direct inhibition of MYC by a small-molecule drug has not reached clinical testing. MYC is a transcription factor that depends on several binding partners to function. We therefore explored the possibility of targeting MYC via its interactome in pancreatic ductal adenocarcinoma (PDAC). Design: To identify the most suitable targets among all MYC binding partners, we constructed a targeted shRNA library and performed screens in cultured PDAC cells and tumorstumours in mice.Results:Unexpectedly, many MYC binding partners were found to be important for cultured PDAC cells but dispensable in vivo. more...

Organism:: Mus musculus; synthetic construct

Type:: Other

Platforms:: GPL19057 GPL19424
20 Samples

Download data: CSV

Series

Accession:: GSE216091

ID:: 200216091

PubMed Full text in PMC Similar studies

Select item 1000194242.

Illumina NextSeq 500 (synthetic construct)

Organism:: synthetic construct

108 Series
1081 Samples

Platform

Accession:: GPL19424

ID:: 100019424

Select item 1000190573.

Illumina NextSeq 500 (Mus musculus)

Organism:: Mus musculus

10143 Series
291885 Samples

Platform

Accession:: GPL19057

ID:: 100019057

Select item 3066583964.

KPC_allograft_screen_preexperiment_Ctrl_100k

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658396

ID:: 306658396

SRA Run Selector

Select item 3066583955.

KPC_allograft_screen_preexperiment_Ctrl_50k

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658395

ID:: 306658395

SRA Run Selector

Select item 3066583946.

KPC_allograft_screen_preexperiment_Input_cells

Organism:: Mus musculus

Source name:: NA

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658394

ID:: 306658394

SRA Run Selector

Select item 3066583927.

KPC_allograft_screen_Dox_R5

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658392

ID:: 306658392

SRA Run Selector

Select item 3066583918.

KPC_allograft_screen_Dox_R4

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658391

ID:: 306658391

SRA Run Selector

Select item 3066583909.

KPC_allograft_screen_Dox_R3

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658390

ID:: 306658390

SRA Run Selector

Select item 30665838910.

KPC_allograft_screen_Dox_R2

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658389

ID:: 306658389

SRA Run Selector

Select item 30665838811.

KPC_allograft_screen_Dox_R1

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658388

ID:: 306658388

SRA Run Selector

Select item 30665838712.

KPC_allograft_screen_Ctrl_R5

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658387

ID:: 306658387

SRA Run Selector

Select item 30665838613.

KPC_allograft_screen_Ctrl_R4

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658386

ID:: 306658386

SRA Run Selector

Select item 30665838514.

KPC_allograft_screen_Ctrl_R3

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658385

ID:: 306658385

SRA Run Selector

Select item 30665838415.

KPC_allograft_screen_Ctrl_R2

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658384

ID:: 306658384

SRA Run Selector

Select item 30665838316.

KPC_allograft_screen_Ctrl_R1

Organism:: Mus musculus

Source name:: tumor

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658383

ID:: 306658383

SRA Run Selector

Select item 30665838217.

KPC_culture_screen_Dox_R3

Organism:: Mus musculus

Source name:: NA

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658382

ID:: 306658382

SRA Run Selector

Select item 30665838118.

KPC_culture_screen_Dox_R2

Organism:: Mus musculus

Source name:: NA

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658381

ID:: 306658381

SRA Run Selector

Select item 30665838019.

KPC_culture_screen_Dox_R1

Organism:: Mus musculus

Source name:: NA

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658380

ID:: 306658380

SRA Run Selector

Select item 30665837920.

KPC_culture_screen_Ctrl_R3

Organism:: Mus musculus

Source name:: NA

Platform:: GPL19057
Series:: GSE216091 GSE216095

Sample

Accession:: GSM6658379

ID:: 306658379

SRA Run Selector

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GSE216091[Accession] (23)
GEO DataSets
cytochrome b, partial (mitochondrion) [Heimyscus fumosus]
cytochrome b, partial (mitochondrion) [Heimyscus fumosus]
gi|387763851|gb|AFJ94723.1|

Protein
hypothetical protein LRAMOSA05979 [Lichtheimia ramosa]
hypothetical protein LRAMOSA05979 [Lichtheimia ramosa]
gi|671684788|emb|CDS13805.1|

Protein
stannin [Latimeria chalumnae]
stannin [Latimeria chalumnae]
gi|557023688|ref|XP_006012053.1|

Protein
Chain L, V-type proton ATPase subunit G
Chain L, V-type proton ATPase subunit G
gi|1035439084|pdb|5BW9|L

Protein

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