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Items: 14

1.

The menin inhibitor SNDX-5613 for KMT2A rearranged or NPM1 mutant leukemia

(Submitter supplied) Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue function. The interaction of menin with lysine methyltransferase 2A (KMT2A), an epigenetic regulator, is a dependency in acute leukaemia caused by either rearrangement of KMT2A or mutation in Nucleophosmin 1(NPM1). KMT2A rearrangements occur in up to 10% of acute leukaemias and have an adverse prognosis whereas NPM1 mutations occur in up to 30%, forming the most common genetic alteration in acute myeloid leukaemia7,8. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL18573
12 Samples
Download data: CSV, TDF, TXT
Series
Accession:
GSE216730
ID:
200216730
2.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
3.

DFAM22359_NPM1c_SNDX5613_7d_rep3

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689655
ID:
306689655
4.

DFAM22359_NPM1c_SNDX5613_7d_rep2

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689654
ID:
306689654
5.

DFAM22359_NPM1c_SNDX5613_7d_rep1

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689653
ID:
306689653
6.

DFAM22359_NPM1c_vehicle_7d_rep3

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689652
ID:
306689652
7.

DFAM22359_NPM1c_vehicle_7d_rep2

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689651
ID:
306689651
8.

DFAM22359_NPM1c_vehicle_7d_rep1

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689650
ID:
306689650
9.

CBAM68552_MLL-AF6_SNDX5613_7d_rep3

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689649
ID:
306689649
10.

CBAM68552_MLL-AF6_SNDX5613_7d_rep2

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689648
ID:
306689648
11.

CBAM68552_MLL-AF6_SNDX5613_7d_rep1

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689647
ID:
306689647
12.

CBAM68552_MLL-AF6_vehicle_7d_rep3

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689646
ID:
306689646
13.

CBAM68552_MLL-AF6_vehicle_7d_rep2

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689645
ID:
306689645
14.

CBAM68552_MLL-AF6_vehicle_7d_rep1

Organism:
Homo sapiens
Source name:
bone marrow
Platform:
GPL18573
Series:
GSE216730
Download data: TDF
Sample
Accession:
GSM6689644
ID:
306689644
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Supplemental Content

db=gds|term=GSE216730[Accession]|query=4|qty=2|blobid=MCID_66aa876b59d5283fa9562b73|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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