GSE222612[Accession] - GEO DataSets - NCBI

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Select item 2002226121.

Pan-cancer analysis revealed H3K4me1 at bivalent promoters premarks DNA hypermethylation during tumor development and identified the regulatory role of DNA methylation in relation to histone modifications

(Submitter supplied) Background: DNA hypermethylation at promoter CpG islands (CGIs) is a hallmark of cancers and could lead to dysregulation of gene expression in the development of cancers, however, its dynamics and regulatory mechanisms remain elusive. Bivalent genes, that direct development and differentiation of stem cells, are found to be frequent targets of hypermethylation in cancers. Results: Here we performed comprehensive analysis across multiple cancer types and identified that the decrease in H3K4me1 levels coincides with DNA hypermethylation at the bivalent promoter CGIs during tumorigenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL16791
28 Samples

Download data: BW, COV

Series

Accession:: GSE222612

ID:: 200222612

PubMed Full text in PMC Similar studies

Select item 1000167912.

Illumina HiSeq 2500 (Homo sapiens)

Organism:: Homo sapiens

12139 Series
348714 Samples

Platform

Accession:: GPL16791

ID:: 100016791

Select item 3069277813.

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222611 GSE222612

Download data: COV

Sample

Accession:: GSM6927781

ID:: 306927781

SRA Run Selector

Select item 3069277804.

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222611 GSE222612

Download data: COV

Sample

Accession:: GSM6927780

ID:: 306927780

SRA Run Selector

Select item 3069277795.

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222611 GSE222612

Download data: COV

Sample

Accession:: GSM6927779

ID:: 306927779

SRA Run Selector

Select item 3069277786.

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222611 GSE222612

Download data: COV

Sample

Accession:: GSM6927778

ID:: 306927778

SRA Run Selector

Select item 3069254227.

LSD1_NCM460_OE_H3K4me3

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925422

ID:: 306925422

SRA Run Selector

Select item 3069254218.

LSD1_NCM460_OE_H3K4me1

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925421

ID:: 306925421

SRA Run Selector

Select item 3069254209.

LSD1_NCM460_OE_input

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925420

ID:: 306925420

SRA Run Selector

Select item 30692541910.

LSD1_NCM460_NC_H3K4me3

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925419

ID:: 306925419

SRA Run Selector

Select item 30692541811.

LSD1_NCM460_NC_H3K4me1

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925418

ID:: 306925418

SRA Run Selector

Select item 30692541712.

LSD1_NCM460_NC_input

Organism:: Homo sapiens

Source name:: NCM460

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925417

ID:: 306925417

SRA Run Selector

Select item 30692541613.

LSD1_HCT116_KO_H3K4me3_rep2

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925416

ID:: 306925416

SRA Run Selector

Select item 30692541514.

LSD1_HCT116_KO_H3K4me3_rep1

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925415

ID:: 306925415

SRA Run Selector

Select item 30692541415.

LSD1_HCT116_KO_H3K4me1_rep2

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925414

ID:: 306925414

SRA Run Selector

Select item 30692541316.

LSD1_HCT116_KO_H3K4me1_rep1

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925413

ID:: 306925413

SRA Run Selector

Select item 30692541217.

LSD1_HCT116_KO_input_rep2

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925412

ID:: 306925412

SRA Run Selector

Select item 30692541118.

LSD1_HCT116_KO_input_rep1

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925411

ID:: 306925411

SRA Run Selector

Select item 30692541019.

LSD1_HCT116_WT_H3K4me3_rep2

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925410

ID:: 306925410

SRA Run Selector

Select item 30692540920.

LSD1_HCT116_WT_H3K4me3_rep1

Organism:: Homo sapiens

Source name:: HCT116

Platform:: GPL16791
Series:: GSE222523 GSE222612

Download data: BW

Sample

Accession:: GSM6925409

ID:: 306925409

SRA Run Selector

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