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1.

G-quadruplex DNA structure is a positive regulator of MYC transcription

(Submitter supplied) DNA structure can regulate genome function. Four-stranded DNA G-quadruplex (G4) structures have been implicated in transcriptional regulation; however, previous studies have not directly addressed the role of an individual G4 within its endogenous cellular context. Using CRISPR to genetically abrogate endogenous G4 structure folding, we directly interrogate the G4 found within the upstream regulatory region of the critical human MYC oncogene. more...
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by high throughput sequencing; Other; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL30173 GPL18573 GPL19057
243 Samples
Download data: BW, TXT, XLSX
Series
Accession:
GSE223370
ID:
200223370
2.

NextSeq 2000 (Homo sapiens)

Platform
Accession:
GPL30173
ID:
100030173
3.

Illumina NextSeq 500 (Mus musculus)

Platform
Accession:
GPL19057
ID:
100019057
4.

Illumina NextSeq 500 (Homo sapiens)

Platform
Accession:
GPL18573
ID:
100018573
5.

TPL_WT_30m_input

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815911
ID:
307815911
6.

TPL_WT_2h_input

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815910
ID:
307815910
7.

TPL_WT_1h_input

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815909
ID:
307815909
8.

TPL_WT_0h_input

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815908
ID:
307815908
9.

TPL_RNAPIIS5P_WT_30m_B3

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815907
ID:
307815907
10.

TPL_RNAPIIS5P_WT_30m_B2

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815906
ID:
307815906
11.

TPL_RNAPIIS5P_WT_30m_B1

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815905
ID:
307815905
12.

TPL_RNAPIIS5P_WT_2h_B3

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815904
ID:
307815904
13.

TPL_RNAPIIS5P_WT_2h_B2

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815903
ID:
307815903
14.

TPL_RNAPIIS5P_WT_2h_B1

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815902
ID:
307815902
15.

TPL_RNAPIIS5P_WT_1h_B3

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815901
ID:
307815901
16.

TPL_RNAPIIS5P_WT_1h_B2

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815900
ID:
307815900
17.

TPL_RNAPIIS5P_WT_1h_B1

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815899
ID:
307815899
18.

TPL_RNAPIIS5P_WT_0h_B3

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815898
ID:
307815898
19.

TPL_RNAPIIS5P_WT_0h_B2

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815897
ID:
307815897
20.

TPL_RNAPIIS5P_WT_0h_B1

Organism:
Homo sapiens
Source name:
HEK293T
Platform:
GPL30173
Series:
GSE223370
Download data: BW
Sample
Accession:
GSM7815896
ID:
307815896
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Supplemental Content

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