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Items: 20

1.

β2-adrenergic receptor transcriptional response in HEK293 wild type, β-arrestin1/2 KO and Gαs KO cells upon isoproterenol stimulation.

(Submitter supplied) The role of nuclear signaling by β2-adrenergic receptor (β2AR) through β-arrestins in the absence of a functional Gαs protein has not been evaluated. This has prevented a comprehensive understanding of the relative contribution of Gαs and β-arrestins to the overall β2AR signaling, thereby limiting our appreciation of how β-arrestin- or Gαs-biased ligands may affect their therapeutic outcomes. To explore the role of Gαs and β-arrestin in nuclear transcriptional programs in a global unbiased approach, we performed RNA sequencing studies in cells lacking either of these two signaling arms downstream from β2AR, followed by detailed bioinformatics analysis of gene expression signatures. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24676
18 Samples
Download data: CSV
Series
Accession:
GSE245270
ID:
200245270

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.

Illumina NovaSeq 6000 (Homo sapiens)

Organism:
Homo sapiens
17049 Series
931958 Samples
Download data
Platform
Accession:
GPL24676
ID:
100024676

3.

HEK293 cells, βarrestin1/2 KO, isoproterenol, biol rep 3

Organism:
Homo sapiens
Source name:
βarrestin1/2 knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840060
ID:
307840060

SRA Run Selector

4.

HEK293 cells, βarrestin1/2 KO, isoproterenol, biol rep 2

Organism:
Homo sapiens
Source name:
βarrestin1/2 knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840059
ID:
307840059

SRA Run Selector

5.

HEK293 cells, βarrestin1/2 KO, isoproterenol, biol rep 1

Organism:
Homo sapiens
Source name:
βarrestin1/2 knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840058
ID:
307840058

SRA Run Selector

6.

HEK293 cells, βarrestin1/2 KO, basal, biol rep 3

Organism:
Homo sapiens
Source name:
βarrestin1/2 knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840057
ID:
307840057

SRA Run Selector

7.

HEK293 cells, βarrestin1/2 KO, basal, biol rep 2

Organism:
Homo sapiens
Source name:
βarrestin1/2 knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840056
ID:
307840056

SRA Run Selector

8.

HEK293 cells, βarrestin1/2 KO, basal, biol rep 1

Organism:
Homo sapiens
Source name:
βarrestin1/2 knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840055
ID:
307840055

SRA Run Selector

9.

HEK293 cells, Gαs KO, isoproterenol, biol rep 3

Organism:
Homo sapiens
Source name:
Gαs knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840054
ID:
307840054

SRA Run Selector

10.

HEK293 cells, Gαs KO, isoproterenol, biol rep 2

Organism:
Homo sapiens
Source name:
Gαs knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840053
ID:
307840053

SRA Run Selector

11.

HEK293 cells, Gαs KO, isoproterenol, biol rep 1

Organism:
Homo sapiens
Source name:
Gαs knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840052
ID:
307840052

SRA Run Selector

12.

HEK293 cells, Gαs KO, basal, biol rep 3

Organism:
Homo sapiens
Source name:
Gαs knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840051
ID:
307840051

SRA Run Selector

13.

HEK293 cells, Gαs KO, basal, biol rep 2

Organism:
Homo sapiens
Source name:
Gαs knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840050
ID:
307840050

SRA Run Selector

14.

HEK293 cells, Gαs KO, basal, biol rep 1

Organism:
Homo sapiens
Source name:
Gαs knock out
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840049
ID:
307840049

SRA Run Selector

15.

HEK293 cells, wild type, isoproterenol, biol rep 3

Organism:
Homo sapiens
Source name:
wild type
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840048
ID:
307840048

SRA Run Selector

16.

HEK293 cells, wild type, isoproterenol, biol rep 2

Organism:
Homo sapiens
Source name:
wild type
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840047
ID:
307840047

SRA Run Selector

17.

HEK293 cells, wild type, isoproterenol, biol rep 1

Organism:
Homo sapiens
Source name:
wild type
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840046
ID:
307840046

SRA Run Selector

18.

HEK293 cells, wild type, basal, biol rep 3

Organism:
Homo sapiens
Source name:
wild type
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840045
ID:
307840045

SRA Run Selector

19.

HEK293 cells, wild type, basal, biol rep 2

Organism:
Homo sapiens
Source name:
wild type
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840044
ID:
307840044

SRA Run Selector

20.

HEK293 cells, wild type, basal, biol rep 1

Organism:
Homo sapiens
Source name:
wild type
Platform:
GPL24676
Series:
GSE245270
Download data
Sample
Accession:
GSM7840043
ID:
307840043

SRA Run Selector

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