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Items: 13

1.

Combined absence of Trp53 target genes Zmat3, Puma and p21 cause a high incidence of cancer in mice

(Submitter supplied) Transcriptional activation of target genes is essential for TP53-mediated tumour suppression, though the roles of the diverse TP53-activated target genes in tumour suppression remains poorly understood. Knockdown of Zmat3, an RNA-binding zinc-finger protein involved in regulating alternative splicing, in haematopoietic cells by shRNA caused leukaemia only with the concomitant absence of the Puma and p21, the critical effectors of Trp53-mediated apoptosis and cell cycle arrest respectively. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30172
11 Samples
Download data: TXT
Series
Accession:
GSE248747
ID:
200248747
2.

NextSeq 2000 (Mus musculus)

Platform
Accession:
GPL30172
ID:
100030172
3.

Zmat3 -/- Puma -/- p21 -/- 3

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919408
ID:
307919408
4.

Zmat3 -/- Puma -/- p21 -/- 2

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919407
ID:
307919407
5.

Zmat3 -/- Puma -/- p21 -/- 1

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919406
ID:
307919406
6.

Zmat3 -/- 4

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919405
ID:
307919405
7.

Zmat3 -/- 3

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919404
ID:
307919404
8.

Zmat3 -/- 2

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919403
ID:
307919403
9.

Zmat3 -/- 1

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919402
ID:
307919402
10.

Wild-type 4

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919401
ID:
307919401
11.

Wild-type 3

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919400
ID:
307919400
12.

Wild-type 2

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919399
ID:
307919399
13.

Wild-type 1

Organism:
Mus musculus
Source name:
thymus
Platform:
GPL30172
Series:
GSE248747
Download data
Sample
Accession:
GSM7919398
ID:
307919398
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Supplemental Content

db=gds|term=GSE248747[Accession]|query=1|qty=2|blobid=MCID_669d135357bd0c11909c5319|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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