GEO DataSets

(Submitter supplied) Current cancer immunotherapies inducing type 1 immunity-centric anti-tumor responses have achieved dramatic clinical success but seldom led to long-term remission in part due to T cell exhaustion associated dysfunction. It remains unknown whether and how type 2 immunity can be orchestrated with type 1 immunity-based therapies to achieve long-lasting responses. Here, we show that an interleukin-4 fusion protein (Fc–IL-4), a type 2 cytokine, directly acts on terminally exhausted CD8+ T (CD8+ TTE) cells and specifically enhances their effector function and survival. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:

GPL21103 GPL24247

6 Samples

Download data: H5, MTX, TBI, TSV