GEO DataSets

(Submitter supplied) Objective: To study if diabetic and insulin-resistant states lead to mitochondrial dysfunction in the liver, or alternatively, if there is adaption of mitochondrial function to these states in the long-term range. Results: High-fat diet (HFD) caused insulin resistance and severe hepatic lipid accumulation, but respiratory chain parameters were unchanged. Livers from insulin-resistant IR/IRS-1+/- mice had normal lipid contents and normal respiratory chain parameters, however showed mitochondrial uncoupling. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4845

Platform:

GPL6246

13 Samples

Download data: CEL

Analysis of liver from C57BL/6N males treated with streptozotocin (STZ) to induce type 1 diabetes (T1D). Liver mitochondria of STZ males showed increased oxygen consumption. Results provide insight into molecular mechanisms underlying the enhanced performance of T1D STZ liver mitochondria.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL6246

Series:

GSE39752

13 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2504 Series

28 Related Platforms

30419 Samples

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