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(Submitter supplied) Canonical IKK/NF-κB signaling is a master regulator of inflammation and innate immunity and has been implicated in the pathogenesis of T1D. To investigate the impact of NF-κB activation on β-cell homeostasis and diabetes development, we generated a transgenic gain-of-function mouse model allowing conditional NF-κB activation via expression of IKK2-CA (constitutively active IKK2 allele) in β-cells using the tetracycline-regulated gene expression system. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4933

Platform:

GPL6246

14 Samples

Download data: CEL

Analysis of islets from 11-week-old Inhibitor of κB kinase 2/pancreatic and duodenal homeobox 1 transgenics. The IKK2/Pdx-1 model allows activation of proinflammatory IKK2/NF-κB signaling, specific to β-cells. Results provide insight into molecular consequences of NF-κB activation in β-cells.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:

GPL6246

Series:

GSE47504

14 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: See manufacturer's web site

Organism:

Mus musculus

143 DataSets

2499 Series

28 Related Platforms

30153 Samples

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