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Items: 7

1.

Activation-induced cytidine deaminase acts as a mutator in BCR-ABL1-transformed acute lymphoblastic leukemia cells

(Submitter supplied) The Philadelphia chromosome (Ph) encoding the oncogenic BCR-ABL1 kinase defines a subset of ALL with a particularly unfavorable prognosis. Acute lymphoblastic leukemia (ALL) cells are derived from B cell precursors in most cases and typically carry rearranged immunglobulin heavy chain (IGH) variable (V) region genes devoid of somatic mutations. Somatic hypermutation is restricted to mature germinal center B cells and depends on activation-induced cytidine deaminase (AID). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS2706
Platform:
GPL571
4 Samples
Download data: CEL
Series
Accession:
GSE7182
ID:
200007182
2.
Full record GDS2706

Philadelphia chromosome positive acute lymphoblastic leukemia cell lines response to imatinib mesylate

Analysis of Philadelphia chromosome (Ph) positive acute lymphoblastic leukemia cell lines BV173 and SUP-B15 treated with the anticancer drug imatinib mesylate (STI571). Ph encodes the oncogenic BCR-ABL1 kinase. Results provide insight into molecular basis of the transforming activity of BCR-ABL1.
Organism:
Homo sapiens
Type:
Expression profiling by array, count, 2 agent, 2 cell line sets
Platform:
GPL571
Series:
GSE7182
4 Samples
Download data: CEL
3.

[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 08, 2012: annotation table updated with netaffx build 32 July 01, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Human Genome U133A 2.0 Array is a single array representing 14,500 well-characterized human genes that can be used to explore human biology and disease processes. more...
Organism:
Homo sapiens
84 DataSets
641 Series
12 Related Platforms
24467 Samples
Download data
Platform
Accession:
GPL571
ID:
100000571
4.

SUP-B15 treated

Organism:
Homo sapiens
Source name:
Cell line SUP-B15
Platform:
GPL571
Series:
GSE7182
Dataset:
GDS2706
Download data: CEL
Sample
Accession:
GSM172886
ID:
300172886
5.

SUP-B15 untreated

Organism:
Homo sapiens
Source name:
Cell line SUP-B15
Platform:
GPL571
Series:
GSE7182
Dataset:
GDS2706
Download data: CEL
Sample
Accession:
GSM172885
ID:
300172885
6.

BV-173 treated

Organism:
Homo sapiens
Source name:
Cell line BV-173
Platform:
GPL571
Series:
GSE7182
Dataset:
GDS2706
Download data: CEL
Sample
Accession:
GSM172884
ID:
300172884
7.

BV-173 untreated

Organism:
Homo sapiens
Source name:
Cell line BV-173
Platform:
GPL571
Series:
GSE7182
Dataset:
GDS2706
Download data: CEL
Sample
Accession:
GSM172883
ID:
300172883

Supplemental Content

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