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Items: 8

1.

Dnmt3a haploinsufficiency transforms Flt3-ITD myeloproliferative disease into a rapid, spontaneous, and fully-penetrant acute myeloid leukemia (Bulk RNA-Seq)

(Submitter supplied) Cytogenetically normal acute myeloid leukemia (CN-AML) represents nearly 50% of human acute myeloid leukemia (AML) cases with a 5-year overall survival of approximately 30%. In CN-AML with poorer prognosis, mutations in the de novo DNA methyltransferase (DNMT3A) and the FMS-like tyrosine kinase 3 (Flt3) commonly co-occur (1-3). We demonstrate that mice with Flt3-internal-tandem duplication (Flt3ITD) and inducible deletion of Dnmt3a spontaneously develop a rapidly-lethal, completely-penetrant, and transplantable AML of normal karyotype. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL17021
6 Samples
Download data: TXT
Series
Accession:
GSE77846
ID:
200077846

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11095 Series
299192 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

3.

9927 Flt3ITD/ITD,Dnmt3afl/fl MPN

Organism:
Mus musculus
Source name:
primary MPN
Platform:
GPL17021
Series:
GSE77846 GSE77849
Download data
Sample
Accession:
GSM2060317
ID:
302060317

SRA Run Selector

4.

9798 Flt3ITD/ITD,Dnmt3afl/fl MPN

Organism:
Mus musculus
Source name:
primary MPN
Platform:
GPL17021
Series:
GSE77846 GSE77849
Download data
Sample
Accession:
GSM2060316
ID:
302060316

SRA Run Selector

5.

9796 Flt3ITD/ITD,Dnmt3afl/fl MPN

Organism:
Mus musculus
Source name:
primary MPN
Platform:
GPL17021
Series:
GSE77846 GSE77849
Download data
Sample
Accession:
GSM2060315
ID:
302060315

SRA Run Selector

6.

9797 Flt3ITD/ITD,Dnmt3afl/- MxCre AML

Organism:
Mus musculus
Source name:
primary AML
Platform:
GPL17021
Series:
GSE77846 GSE77849
Download data
Sample
Accession:
GSM2060314
ID:
302060314

SRA Run Selector

7.

9301 Flt3ITD/ITD,Dnmt3afl/- MxCre AML

Organism:
Mus musculus
Source name:
primary AML
Platform:
GPL17021
Series:
GSE77846 GSE77849
Download data
Sample
Accession:
GSM2060313
ID:
302060313

SRA Run Selector

8.

8303 Flt3ITD/ITD,Dnmt3afl/- MxCre AML

Organism:
Mus musculus
Source name:
primary AML
Platform:
GPL17021
Series:
GSE77846 GSE77849
Download data
Sample
Accession:
GSM2060312
ID:
302060312

SRA Run Selector

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db=gds|term=GSE77846[Accession]|query=2|qty=2|blobid=MCID_672ae089098d4d3459324a5e|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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