GSE79457[Accession] - GEO DataSets - NCBI

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Select item 2000794571.

Converting adult pancreatic α-cells into β-cells by targeting Dnmt1 and Arx

(Submitter supplied) After their destruction in adult mice, insulin-producing pancreatic beta-cells slowly regenerate from other islet cells, like glucagon-producing alpha-cells. However the molecular basis of this conversion is unknown. Moreover it remains unclear if this intra-islet cell conversion is relevant to human diseases with extensive beta-cell loss, like in type 1 diabetes (T1D). Here, we show that subsets of glucagon-expressing cells in subjects with T1D produce Insulin and other molecular features of beta-cells, accompanied by loss of the alpha-cell regulators DNA methyltransferase 1 (Dnmt1) and Aristaless-related homeobox (Arx). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
182 Samples

Download data: CSV

Series

Accession:: GSE79457

ID:: 200079457

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000190572.

Illumina NextSeq 500 (Mus musculus)

Organism:: Mus musculus

9731 Series
284210 Samples

Platform

Accession:: GPL19057

ID:: 100019057

Select item 3020968673.

mouse_YFPpos_12w_cell182

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell182

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096867

ID:: 302096867

SRA Run Selector

Select item 3020968664.

mouse_YFPpos_12w_cell181

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell181

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096866

ID:: 302096866

SRA Run Selector

Select item 3020968655.

mouse_control_contr_cell180

Organism:: Mus musculus

Source name:: Single cell from pancreas, control_contr_cell180

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096865

ID:: 302096865

SRA Run Selector

Select item 3020968646.

mouse_YFPpos_12w_cell179

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell179

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096864

ID:: 302096864

SRA Run Selector

Select item 3020968637.

mouse_YFPpos_12w_cell178

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell178

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096863

ID:: 302096863

SRA Run Selector

Select item 3020968628.

mouse_YFPpos_12w_cell177

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell177

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096862

ID:: 302096862

SRA Run Selector

Select item 3020968619.

mouse_control_contr_cell176

Organism:: Mus musculus

Source name:: Single cell from pancreas, control_contr_cell176

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096861

ID:: 302096861

SRA Run Selector

Select item 30209686010.

mouse_YFPpos_12w_cell175

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell175

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096860

ID:: 302096860

SRA Run Selector

Select item 30209685911.

mouse_YFPpos_12w_cell174

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell174

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096859

ID:: 302096859

SRA Run Selector

Select item 30209685812.

mouse_YFPpos_12w_cell173

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell173

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096858

ID:: 302096858

SRA Run Selector

Select item 30209685713.

mouse_YFPpos_12w_cell172

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell172

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096857

ID:: 302096857

SRA Run Selector

Select item 30209685614.

mouse_YFPpos_12w_cell171

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell171

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096856

ID:: 302096856

SRA Run Selector

Select item 30209685515.

mouse_YFPpos_12w_cell170

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell170

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096855

ID:: 302096855

SRA Run Selector

Select item 30209685416.

mouse_YFPpos_12w_cell169

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell169

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096854

ID:: 302096854

SRA Run Selector

Select item 30209685317.

mouse_YFPpos_12w_cell168

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell168

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096853

ID:: 302096853

SRA Run Selector

Select item 30209685218.

mouse_YFPpos_12w_cell167

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell167

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096852

ID:: 302096852

SRA Run Selector

Select item 30209685119.

mouse_YFPpos_12w_cell166

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell166

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096851

ID:: 302096851

SRA Run Selector

Select item 30209685020.

mouse_YFPpos_12w_cell165

Organism:: Mus musculus

Source name:: Single cell from pancreas, YFPpos_12w_cell165

Platform:: GPL19057
Series:: GSE79457

Download data: CSV

Sample

Accession:: GSM2096850

ID:: 302096850

SRA Run Selector

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