GSE81628[Accession] - GEO DataSets - NCBI

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Integrative genomics outlines a biphasic glucose response and a ChREBP-RORγ axis regulating proliferation in β-cells

(Submitter supplied) Glucose is an important regulator of pancreatic β-cell function. In addition to the acute stimulation of insulin secretion, glucose stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β-cells. The glucose-sensing transcription factor carbohydrate response element binding protein (ChREBP) has been shown to promote both β-cell proliferation and dysfunction; however, the molecular mechanisms underlying these pleiotropic effects of ChREBP and glucose are not well understood. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18404
54 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE81628

ID:: 200081628

PubMed Similar studies SRA Run Selector

Select item 1000184042.

Illumina HiSeq 1500 (Rattus norvegicus)

Organism:: Rattus norvegicus

17 Series
268 Samples

Platform

Accession:: GPL18404

ID:: 100018404

Select item 3021600003.

DNase I 12h glucose

Organism:: Rattus norvegicus

Source name:: β-cell_DNase I 12h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2160000

ID:: 302160000

SRA Run Selector

Select item 3021599994.

DNase I 2h glucose

Organism:: Rattus norvegicus

Source name:: β-cell_DNase I 2h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159999

ID:: 302159999

SRA Run Selector

Select item 3021599985.

DNase I 0h glucose

Organism:: Rattus norvegicus

Source name:: β-cell_DNase I 0h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159998

ID:: 302159998

SRA Run Selector

Select item 3021599976.

Organism:: Rattus norvegicus

Source name:: β-cell_Input 12h

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159997

ID:: 302159997

SRA Run Selector

Select item 3021599967.

Organism:: Rattus norvegicus

Source name:: β-cell_Input 2h

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159996

ID:: 302159996

SRA Run Selector

Select item 3021599958.

Organism:: Rattus norvegicus

Source name:: β-cell_Input 0h

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159995

ID:: 302159995

SRA Run Selector

Select item 3021599949.

ChREBP 12h glucose B

Organism:: Rattus norvegicus

Source name:: β-cell_ChREBP 12h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159994

ID:: 302159994

SRA Run Selector

Select item 30215999310.

ChREBP 12h glucose A

Organism:: Rattus norvegicus

Source name:: β-cell_ChREBP 12h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159993

ID:: 302159993

SRA Run Selector

Select item 30215999211.

ChREBP 2h glucose B

Organism:: Rattus norvegicus

Source name:: β-cell_ChREBP 2h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159992

ID:: 302159992

SRA Run Selector

Select item 30215999112.

ChREBP 2h glucose A

Organism:: Rattus norvegicus

Source name:: β-cell_ChREBP 2h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159991

ID:: 302159991

SRA Run Selector

Select item 30215999013.

ChREBP 0h glucose B

Organism:: Rattus norvegicus

Source name:: β-cell_ChREBP 0h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159990

ID:: 302159990

SRA Run Selector

Select item 30215998914.

ChREBP 0h glucose A

Organism:: Rattus norvegicus

Source name:: β-cell_ChREBP 0h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159989

ID:: 302159989

SRA Run Selector

Select item 30215998815.

MED1 12h glucose B

Organism:: Rattus norvegicus

Source name:: β-cell_MED1 12h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159988

ID:: 302159988

SRA Run Selector

Select item 30215998716.

MED1 12h glucose A

Organism:: Rattus norvegicus

Source name:: β-cell_MED1 12h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159987

ID:: 302159987

SRA Run Selector

Select item 30215998617.

MED1 2h glucose B

Organism:: Rattus norvegicus

Source name:: β-cell_MED1 2h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159986

ID:: 302159986

SRA Run Selector

Select item 30215998518.

MED1 2h glucose A

Organism:: Rattus norvegicus

Source name:: β-cell_MED1 2h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159985

ID:: 302159985

SRA Run Selector

Select item 30215998419.

MED1 0h glucose B

Organism:: Rattus norvegicus

Source name:: β-cell_MED1 0h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159984

ID:: 302159984

SRA Run Selector

Select item 30215998320.

MED1 0h glucose A

Organism:: Rattus norvegicus

Source name:: β-cell_MED1 0h glucose

Platform:: GPL18404
Series:: GSE81628

Download data: BEDGRAPH

Sample

Accession:: GSM2159983

ID:: 302159983

SRA Run Selector

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