GEO DataSets

(Submitter supplied) During immune ontogeny the thymus is colonized by distinct waves of hematopoietic stem cells that give rise to unique lineages of immune cells.  In this report, we asked whether the developmental origin of CD8+ T cells influences their response to infection later in adulthood.  To answer this question, we developed a system to ‘timestamp’ CD8+ T cells in situ at various stages of development (1d and 28d) and examined their behavior at 8 weeks of age.  We found that neonatal-derived CD8+ T cells have an intrinsic propensity to become memory phenotype cells prior to infection and are the first cells to proliferate and become effectors after microbial challenge. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

4 Samples

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