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Items: 3

1.

Loss of imprinting at the CTCF binding sites in the DLK1-DIO3 domain reactivates microRNA expression in acute promyelocytic leukaemia

(Submitter supplied) We report the DNA-methylation profiling of 10 regions selected from the DLK1-DIO3 domain on chromosome 14q32 in BM/PB samples from patients with acute promyelocytic leukaemia (APL), other subclasses of acute myeloid leukaemia and healthy donors, using high-throughput amplicon bisulfite sequencing with Roche 454 technology. We identify monoallelic-hypermethylation in APL only at the differentially methylated region (DMR) located upstream from the MEG3 gene (MEG3-DMR), whereas no changes in the DNA methylation profile were detected at the imprinting control region of the domain (IG-DMR) among the samples analysed. more...
Organism:
Homo sapiens
Type:
Methylation profiling by high throughput sequencing
Platform:
GPL14603
47 Samples
Download data: TXT, WIG
Series
Accession:
GSE42543
ID:
200042543

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2.

454 GS FLX Titanium (Homo sapiens)

Organism:
Homo sapiens
13 Series
146 Samples
Download data
Platform
Accession:
GPL14603
ID:
100014603

3.

AML_CR_18/20

Organism:
Homo sapiens
Source name:
Bone Marrow/Bone Marrow
Platform:
GPL14603
Series:
GSE42543
Download data: WIG
Sample
Accession:
GSM1044717
ID:
301044717

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db=gds|term=GSM1044717[Accession]|query=1|qty=2|blobid=MCID_672f7824e6e18526434d31c4|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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